CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13741
Family Name Angiopoietin-1 receptor and Vascular endothelial growth factor receptor 2 ligand benzimidazole-urea, 51 family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00423990 Functional Category Bioactive
Superfamily Angiopoietin-1 receptor and Vascular endothelial growth factor receptor 2 Binder Superfamily 2
Class Class 1268

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Histamine H1 receptor Ligand Astemizole Family 7 240
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 9 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Neuropeptide Y receptor type 5 and Alpha-1A adrenergic recepto... 8 2
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Melanin-concentrating hormone receptor 1 ligand SureCN3334861 ... 1 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
ALK tyrosine kinase receptor ligand 4-fluoro-N-[1-[4-(propan-2... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(1H-benzimidazole... 1 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 4
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 1 0
Collagenase 3 inhibitor 5-[4-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Sterol O-acyltransferase 1 inhibitor 1-[4-[2-(4,5-diphenyl-1H-... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 5 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Glucokinase inhibitor SureCN1657199 family 10 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00423990 CHEMBL244106 Bioactive benzimidazole-urea, 51
CFAMM00423992 CHEMBL389333 Bioactive benzimidazole-urea, 52

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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