CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13742
Family Name Histone-lysine N-methyltransferase EHMT2 inhibitor N-(1-cyclopropylpiperidin-4-yl)-2-(1,1-dioxo-1,4-thiazinan-4-yl)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine family
No. of Seeds 1 No. of Other Members 2
Family Centroid CFAMM00423995 Functional Category Bioactive
Superfamily Histone-lysine N-methyltransferase EHMT2 and Glucose-dependent insulinotropic receptor Binder Superfamily
Class Class 1144

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Aurora kinase A inhibitor AGN-PC-00BCUF family 16 43
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Receptor-type tyrosine-protein kinase FLT3 ligand 2-(6,7-dimet... 3 2
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Alpha-1A adrenergic receptor ligand 6,7-dimethoxy-2-[4-[(5-oxi... 3 1
Alpha-1A adrenergic receptor ligand 4-[4-(4-amino-6,7-dimethox... 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Receptor tyrosine-protein kinase erbB-2 and Tyrosine-protein k... 1 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Deoxycytidine kinase inhibitor 2-[5-[4-[(4,6-diaminopyrimidin-... 14 11
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00423995 CHEMBL2441077 Bioactive N-(1-cyclopropylpiperidin-4-yl)-2-(1,1-dioxo-1,4-thiazinan-4-yl)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27043 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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