CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13755
Family Name Histamine receptor H3 ligand N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]cyclopentanecarboxamide family
No. of Seeds 10 No. of Other Members 7
Family Centroid CFAMM00424033 Functional Category Bioactive with Natural Product
Superfamily Histamine receptor H3 Binder Superfamily
Class Class 933

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Motilin receptor Ligand GSK962040 Family 30 457
Kappa-type opioid receptor Ligand Asimadoline Family 14 54
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Androgen receptor Ligand 6-n-propyl -4-trifluoromethylquinolin... 29 13
Aurora kinase B Inhibitor Hesperadin Family 1 1
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 4 24
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 5 14
Cellular tumor antigen p53 inhibitor CHEMBL1554992 family 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(5-nitro-2,3-dihyd... 2 6
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
Histamine H3 receptor and Histamine receptor H3 ligand N-[4-[3... 5 1
Histamine H3 receptor and Histamine receptor H3 ligand 1-cyclo... 3 4
Histamine H3 receptor ligand AGN-PC-0CW63F family 1 1
Histamine receptor H3 ligand N-[2-methyl-4-[3-(2-methylpyrroli... 3 2
Histamine receptor H3 ligand N-[2-methyl-4-[(3S)-3-[(2S)-2-met... 1 0
Histamine receptor H3 ligand N-[4-[3-(2-methylpyrrolidin-1-yl)... 2 0
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Dipeptidyl peptidase 4 inhibitor 4-[[(3S,5S)-5-[(2S)-2-cyanopy... 4 12
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
Dipeptidyl peptidase 4 inhibitor (2S,4S)-1-[2-[[1-[4-cyano-2-(... 2 0
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00424032 CHEMBL2441641 Bioactive 2,2,3,3-tetramethyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]cyclopropane-1-carboxamide
CFAMM00424024 CHEMBL2441636 Bioactive N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]oxane-4-carboxamide
CFAMM00424031 CHEMBL2441663 Bioactive AGN-PC-04XUZT
CFAMM00424037 CHEMBL2441647 Bioactive N-[2-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]cyclopropanecarboxamide
CFAMM00424028 CHEMBL2441638 Bioactive N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]cyclohexanecarboxamide
CFAMM00424027 CHEMBL2441654 Bioactive SureCN222487
CFAMM00424034 CHEMBL2441642 Bioactive 2-cyclopentyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]acetamide
CFAMM00424026 CHEMBL2441656 Bioactive SureCN222655
CFAMM00424033 CHEMBL2441640 Bioactive N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]cyclopentanecarboxamide
CFAMM00424025 CHEMBL2441637 Bioactive N-[2-methyl-4-[(3R)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]oxane-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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