Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database. Cousin Family Names Seeds Members Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151 Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253 Cholecystokinin receptor type A Ligand Tarazepide Family 6 323 Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36 Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179 Reverse transcriptase Inhibitor IDX899 Family 2 118 Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154 D(4) dopamine receptor Ligand SPI-376 Family 7 84 Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93 Cannabinoid receptor 2 Ligand JWH-204 Family 6 10 Cholecystokinin receptor type A Ligand VL-0395 Family 12 117 Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26 14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76 Peroxisome proliferator-activated receptor gamma Ligand 2-chlo... 5 19 Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116 Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32 Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46 cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22 Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72 Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160 Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42 5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10 Cannabinoid receptor 1 ligand AGN-PC-04YSUM family 7 6 Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4 Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13 Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18 cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129 Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9 Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3 Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2 Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14 Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12 Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8 Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4 Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 12 Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 2-... 3 0 Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6 Translocator protein inhibitor N-(4-chlorophenyl)-N-methyl-2-(... 2 0 Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 2 9 C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[acetyl(thio... 6 3 C-C chemokine receptor type 5 and Potassium voltage-gated chan... 8 0 C-C chemokine receptor type 5 ligand 4-[[[[1-[(2R)-4-[(6-chlor... 2 0 Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1 Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6 Disintegrin and metalloproteinase domain-containing protein 17... 7 9 Motilin receptor ligand SureCN2768052 family 3 0 Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3 Acetylcholinesterase inhibitor N-[6-[4-[(6-chloro-1,2,3,4-tetr... 9 0 C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4 C-C chemokine receptor type 5 ligand N-[3-[4-[3-cyclohexyl-5-(... 5 4 Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 5 Substance-P receptor ligand AGN-PC-004REJ family 3 0 Coagulation factor X and Prothrombin inhibitor N,1-bis[(3-carb... 1 1 Poly [ADP-ribose] polymerase 1 inhibitor SureCN4998361 family 1 1 Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1 D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1 Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 1 1 Translocator protein inhibitor 2-(7-Chloro-5-methyl-4-oxo-3-ph... 1 0 P2X purinoceptor 7 inhibitor 2-chloro-N-[(1-hydroxy-3,3-dimeth... 1 8 Poly [ADP-ribose] polymerase 1 inhibitor SureCN3553433 family 22 0
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00424057 CHEMBL2441841 Bioactive
3-(aminomethyl)-6-[[(2S)-1-cyclopropylsulfonylpyrrolidin-2-yl]methyl]-4-(2,4-dichlorophenyl)-2-methyl-7H-pyrrolo[3,4-b]pyridin-5-one CFAMM00424050 CHEMBL2441955 Bioactive
3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-6-(2-oxo-2-piperidin-1-ylethyl)-7H-pyrrolo[3,4-b]pyridin-5-one CFAMM00424056 CHEMBL2441846 Bioactive
2-[3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-7H-pyrrolo[3,4-b]pyridin-6-yl]-N,N-diethylacetamide CFAMM00424049 CHEMBL2441839 Bioactive
3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-6-[[(2S)-oxolan-2-yl]methyl]-7H-pyrrolo[3,4-b]pyridin-5-one CFAMM00424055 CHEMBL2441847 Bioactive
3-[3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-7H-pyrrolo[3,4-b]pyridin-6-yl]-N,N-diethylpropanamide CFAMM00424048 CHEMBL2441838 Bioactive
3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-6-[[(2R)-oxolan-2-yl]methyl]-7H-pyrrolo[3,4-b]pyridin-5-one CFAMM00424054 CHEMBL2441952 Bioactive
2-[3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-7H-pyrrolo[3,4-b]pyridin-6-yl]-N,N-dimethylacetamide CFAMM00424047 CHEMBL2441837 Bioactive
3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-[(2S)-1-methoxypropan-2-yl]-2-methyl-7H-pyrrolo[3,4-b]pyridin-5-one CFAMM00424053 CHEMBL2441953 Bioactive
2-[3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-7H-pyrrolo[3,4-b]pyridin-6-yl]-N-methyl-N-propylacetamide CFAMM00424046 CHEMBL2441836 Bioactive
3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyethyl)-2-methyl-7H-pyrrolo[3,4-b]pyridin-5-one CFAMM00424059 CHEMBL2441848 Bioactive
(2R)-2-[3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-7H-pyrrolo[3,4-b]pyridin-6-yl]-N,N-diethylpropanamide CFAMM00424052 CHEMBL2441951 Bioactive
2-[3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-7H-pyrrolo[3,4-b]pyridin-6-yl]-N-methylacetamide CFAMM00424058 CHEMBL2441840 Bioactive
3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-6-[[(2S)-pyrrolidin-2-yl]methyl]-7H-pyrrolo[3,4-b]pyridin-5-one CFAMM00424051 CHEMBL2441954 Bioactive
3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-6-(2-oxo-2-pyrrolidin-1-ylethyl)-7H-pyrrolo[3,4-b]pyridin-5-one
CFAM Mol ID
External ID
Functional Category
Molecule Name
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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