CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13767
Family Name Caspase-1 and Caspase-8 inhibitor N-[(6S)-3-(benzamidomethyl)-1-[2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]amino]-2-oxoethyl]-7-oxo-5,6-dihydro-2H-azepin-6-yl]naphthalene-2-carboxamide family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00424093 Functional Category Bioactive
Superfamily Caspase-8 and Caspase-1 Binder Superfamily
Class Class 2026

Cousin Family NamesSeedsMembers
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 3 1
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Integrin alpha-V and Integrin beta-3 Inhibitor Cyclo-[-arg-gly... 5 38
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor L-709780 Family 9 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Caspase-1 inhibitor AGN-PC-075AEI family 3 0
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-2-(benzenesulfo... 2 8
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-7-benzamido-N-[... 7 18
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-7-benzamido-N-[... 3 0
Caspase-1 and Caspase-8 inhibitor benzyl (4S,7S,9Z,11aS)-7-ben... 2 0
Caspase-1 and Caspase-8 inhibitor (4S,7S,9Z,11aS)-N-[(3S)-2-hy... 2 3
Caspase-1 and Caspase-8 inhibitor (4S,7S,9Z,11aS)-7-(1-benzoth... 2 3
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 2
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-7-benzamido-4-N... 1 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Breast cancer type 1 susceptibility protein inhibitor (2S)-2-[... 1 0
Caspase-1 and Caspase-8 inhibitor N-[(3S)-2-hydroxy-5-oxooxola... 3 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00424093 CHEMBL397184 Bioactive N-[(6S)-3-(benzamidomethyl)-1-[2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]amino]-2-oxoethyl]-7-oxo-5,6-dihydro-2H-azepin-6-yl]naphthalene-2-carboxamide
CFAMM00424091 CHEMBL411758 Bioactive N-[(6S)-3-[(benzylamino)methyl]-1-[2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]amino]-2-oxoethyl]-7-oxo-5,6-dihydro-2H-azepin-6-yl]naphthalene-2-carboxamide
CFAMM00424089 CHEMBL244229 Bioactive N-[(6S)-3-(benzylsulfanylmethyl)-1-[2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]amino]-2-oxoethyl]-7-oxo-5,6-dihydro-2H-azepin-6-yl]naphthalene-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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