CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13770
Family Name Serine/threonine-protein kinase pim-1 and Serine/threonine-protein kinase pim-2 inhibitor N'-[3-(1,3-benzothiazol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]ethane-1,2-diamine family
No. of Seeds 3 No. of Other Members 6
Family Centroid CFAMM00382962 Functional Category Bioactive
Superfamily and Adenosine receptor A2b Binder Superfamily
Class Class 3914

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Hepatocyte growth factor receptor Ligand SGX523 Family 1 15
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Aurora kinase A Inhibitor ABT-348 Family 20 49
PF-4217903 family 14 65
PF-3758309 family 1 8
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Metabotropic glutamate receptor 5 Ligand 3-(1-pyridin-2-yl-1h-... 3 6
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
Mitogen-activated protein kinase 14 inhibitor 6-[3-amino-5-(2-... 4 9
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
5-hydroxytryptamine receptor 6 ligand AGN-PC-03P3TZ family 6 88
Prothrombin and Histone-lysine N-methyltransferase 2A inhibito... 1 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Adenosine receptor A1 and Adenosine receptor A2b ligand SureCN... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Adenosine kinase inhibitor SureCN8183719 family 2 3
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Serine/threonine-protein kinase Chk1 and Cyclin-A2 inhibitor S... 1 1
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 1 11
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Hepatocyte growth factor receptor ligand 4-[(6-phenyl-[1,2,4]t... 3 6
Metabotropic glutamate receptor 4 and Potassium voltage-gated ... 2 15
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
3-phosphoinositide-dependent protein kinase 1 and MAP kinase-a... 1 5
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 12 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 1
Histamine H3 receptor ligand 2-(3-methyl-[1,2,4]triazolo[4,3-a... 1 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 2
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 2
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 1 0
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 5 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 3
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Cyclooxygenase 2 and Prostaglandin G/H synthase 1 inhibitor Su... 2 1
Corticotropin-releasing factor receptor 1 ligand 2-[1-[1-[4-ni... 2 1
Glycogen synthase kinase-3 beta inhibitor pyrazolopyrimidine d... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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