CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13781
Family Name Egl nine homolog 1 inhibitor 2-(2-methoxy-4-phenylphenyl)-8-[(3-methylpyridin-2-yl)methyl]-2,8-diazaspiro[4.5]decan-1-one family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00424198 Functional Category Bioactive
Superfamily Chymase and Liver carboxylesterase 1 Binder Superfamily
Class Class 963

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Translocator protein inhibitor SureCN13502542 family 20 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 2 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
D(4) dopamine receptor ligand AGN-PC-00SXAZ family 2 4
Transient receptor potential cation channel subfamily V member... 6 1
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 2 6
Mitogen-activated protein kinase 9 and Tyrosine-protein kinase... 2 6
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00424198 CHEMBL2443129 Bioactive 2-(2-methoxy-4-phenylphenyl)-8-[(3-methylpyridin-2-yl)methyl]-2,8-diazaspiro[4.5]decan-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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