CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13790
Family Name Histamine H3 receptor ligand AGN-PC-01WA6E family
No. of Seeds 10 No. of Other Members 1
Family Centroid CFAMM00424260 Functional Category Bioactive
Superfamily Monoamine reuptake, metabotropic transmembrane receptor binder amphetamine Progabide Superfamily
Class Class 49

Cousin Family NamesSeedsMembers
Noradrenergic re-uptake and Serotonin re-uptake inhibitor phen... 18 41
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
Neuromedin-K receptor Ligand Osanetant Family 38 192
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
Bavisant family 9 65
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 10 52
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Sodium-dependent dopamine transporter and Sodium-dependent nor... 10 28
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 4 10
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 2 23
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 3 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 5 11
Sigma non-opioid intracellular receptor 1 ligand N-Phprop-clph... 1 12
Pyruvate kinase PKM and Huntingtin inhibitor CHEMBL1455935 family 1 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 2
Prelamin-A/C and Ras-related protein Rab-9A inhibitor CHEMBL15... 1 7
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 7 16
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Melanin-concentrating hormone receptor 1 ligand 1-(3-acetyl-1,... 8 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 2 0
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 0
Aldose reductase inhibitor SureCN8804611 family 2 0


External ID

Functional Category

Molecule Name

CFAMM00424264 CHEMBL2447991 Bioactive AGN-PC-01WA6S
CFAMM00424263 CHEMBL2447992 Bioactive AGN-PC-01WA6V
CFAMM00424270 CHEMBL319978 Bioactive AGN-PC-009DAL
CFAMM00424262 CHEMBL2447993 Bioactive AGN-PC-01WA6W
CFAMM00424261 CHEMBL2447995 Bioactive AGN-PC-01WA6I
CFAMM00424268 CHEMBL2447986 Bioactive AGN-PC-01WA6D
CFAMM00424260 CHEMBL2447955 Bioactive AGN-PC-01WA6E
CFAMM00424267 CHEMBL2447989 Bioactive AGN-PC-01WA6K
CFAMM00424259 CHEMBL2447956 Bioactive AGN-PC-01WA6O
CFAMM00424266 CHEMBL97170 Bioactive 757183-18-9

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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