CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13791
Family Name Histamine H3 receptor and Sodium-dependent serotonin transporter ligand 3-(3,4-dichlorophenoxy)-N,N-dimethyl-3-[4-(3-piperidin-1-ylpropoxy)phenyl]propan-1-amine;hydrochloride family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00424272 Functional Category Bioactive
Superfamily Sigma non-opioid intracellular receptor 1 and Histamine H3 receptor Binder Superfamily
Class Class 3413

Cousin Family NamesSeedsMembers
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 4 35
Acolbifene family 10 115
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Dipeptidyl peptidase 4 Inhibitor (2-chloro-6-phenoxyphenyl)met... 17 24
C-C chemokine receptor type 5 Ligand N-(2-(4-chlorobenzyloxy)-... 3 13
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Histamine H3 receptor Ligand 1-(3-(2-(3-methoxyphenoxy)ethoxy)... 3 9
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Inhibitor 2... 1 9
D(4) dopamine receptor ligand AGN-PC-0073PO family 7 10
Glutamate receptor ionotropic, NMDA 3A and Glutamate receptor ... 2 1
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Sigma non-opioid intracellular receptor 1 and 3-beta-hydroxyst... 15 11
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... 6 15
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Sodium-dependent serotonin transporter and Sodium-dependent no... 6 21
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-(4-... 2 6
Histamine H1 receptor and C-C chemokine receptor type 3 ligand... 2 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Histamine H3 receptor ligand AGN-PC-0765YW family 1 4
Sodium-dependent noradrenaline transporter and Sodium-dependen... 14 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00424273 CHEMBL245919 Bioactive AGN-PC-04UFVK
CFAMM00424272 CHEMBL2447963 Bioactive 3-(3,4-dichlorophenoxy)-N,N-dimethyl-3-[4-(3-piperidin-1-ylpropoxy)phenyl]propan-1-amine;hydrochloride
CFAMM00424271 CHEMBL245920 Bioactive AGN-PC-04UFQ8

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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