CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1381
Family Name Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8k family
No. of Seeds 4 No. of Other Members 15
Family Centroid CFAMM00185052 Functional Category Bioactive with Natural Product
Superfamily Beta-secretase 1 and Cathepsin S Binder Superfamily
Class Class 1297

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Beta-secretase 1 and Cathepsin D inhibitor 3ixj family 10 21
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Vasopressin V1a receptor and Vasopressin V2 receptor ligand N-... 1 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Stromelysin-1 and 72 kDa type IV collagenase inhibitor [(2S)-2... 2 2
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN5224847 ... 3 24
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Kappa-type opioid receptor ligand AGN-PC-09M90I family 2 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Pol polyprotein inhibitor AC1LA9K7 family 7 23
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Vasopressin V1b receptor ligand AGN-PC-09QGT9 family 4 123
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Microsomal triglyceride transfer protein large subunit inhibit... 3 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 6 3
5-hydroxytryptamine receptor 1B ligand SureCN5352760 family 2 5
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 5
Beta-secretase 1 and Beta-secretase 2 inhibitor 3-(1,1-dioxoth... 6 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 4 4
Beta-secretase 1 inhibitor N-[(2S,3R)-1-(3,5-difluorophenyl)-3... 5 5
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
Cathepsin E and Cathepsin D inhibitor SureCN2529506 family 2 0
Adenosine receptor A2b and Adenosine receptor A1 ligand AGN-PC... 1 2
Angiotensin-converting enzyme inhibitor (6aS,8R)-8-hydroxy-5-[... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00322710 CHEMBL1162922 Bioactive SureCN4798631
CFAMM00322714 CHEMBL203052 Bioactive arylaminoethyl amide, 8n

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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