CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13818
Family Name cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A inhibitor SureCN5794493 family
No. of Seeds 19 No. of Other Members 11
Family Centroid CFAMM00424400 Functional Category Bioactive
Superfamily cAMP and Dipeptidyl peptidase 4 Binder Superfamily
Class Class 866

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Neuromedin-K receptor and Substance-K receptor ligand 2-[2-phe... 2 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Cysteinyl leukotriene receptor 1 and Peripheral myelin protein... 1 1
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... 11 13
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(4-fluo... 7 1
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Cholinesterase and Acetylcholinesterase inhibitor 6-[4-[2-fluo... 17 0
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Protein kinase C theta type and Protein kinase C delta type in... 10 7
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Prothrombin inhibitor AGN-PC-074I2Z family 2 1


External ID

Functional Category

Molecule Name

CFAMM00424389 CHEMBL245709 Bioactive AGN-PC-00D3WV
CFAMM00424402 CHEMBL393646 Bioactive AGN-PC-00C7ZR
CFAMM00424408 CHEMBL247973 Bioactive SureCN8269615
CFAMM00424414 CHEMBL397600 Bioactive SureCN5794495
CFAMM00424407 CHEMBL245710 Bioactive AGN-PC-00ALRK
CFAMM00424387 CHEMBL245984 Bioactive AGN-PC-00AVWB
CFAMM00424400 CHEMBL246798 Bioactive SureCN5794493
CFAMM00424413 CHEMBL392183 Bioactive 2-[[3-cyano-2-[4-(2-ethoxyphenyl)phenyl]-6-fluoroquinolin-4-yl]-methylamino]propanoic acid
CFAMM00424399 CHEMBL246799 Bioactive SureCN8268940
CFAMM00424392 CHEMBL397774 Bioactive SureCN8268994
CFAMM00424405 CHEMBL246141 Bioactive AGN-PC-00D3JC
CFAMM00424385 CHEMBL248380 Bioactive SureCN5795327
CFAMM00424411 CHEMBL248059 Bioactive (2R)-2-[[3-cyano-2-[4-(2-ethoxyphenyl)phenyl]-6-methoxyquinolin-4-yl]amino]propanoic acid
CFAMM00424391 CHEMBL395205 Bioactive SureCN5797056
CFAMM00424404 CHEMBL247159 Bioactive SureCN8268985
CFAMM00424410 CHEMBL248058 Bioactive (2R)-2-[[3-cyano-2-[4-(2-ethoxyphenyl)phenyl]quinolin-4-yl]amino]propanoic acid
CFAMM00424390 CHEMBL245592 Bioactive SureCN5796921
CFAMM00424403 CHEMBL247364 Bioactive SureCN8268965
CFAMM00424409 CHEMBL245788 Bioactive AGN-PC-00DIGL

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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