CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13821
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7-dimethoxyisoquinolin-4-yl)methyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione family
No. of Seeds 6 No. of Other Members 8
Family Centroid CFAMM00424455 Functional Category Bioactive
Superfamily Insulin-like growth factor 1 receptor and Tyrosine-protein kinase JAK2 Binder Superfamily
Class Class 974

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Adenosine receptor A2a Ligand KW-6002 Family 18 195
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Alpha-1A adrenergic receptor Ligand A-131701 Family 16 17
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Adenosine receptor A2b Ligand CVT-7124 Family 14 64
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Divapl... 3 47
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
DNA ligase Inhibitor 7-(4-methoxyphenyl)pteridine-2,4-diol Family 1 4
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 18
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Adenosine receptor A1 and Adenosine receptor A2b ligand 3-meth... 7 19
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-[4-[... 12 15
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 1 2
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 3
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Histamine H3 receptor ligand SureCN7251693 family 3 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Cannabinoid receptor 1 ligand AGN-PC-03I5TW family 3 12
Adenosine receptor A1 and Adenosine receptor A3 ligand SureCN5... 3 1
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 7
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Adenosine receptor A2b ligand 2-[5-(2,6-dioxo-1,3-dipropyl-7H-... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17i ... 3 6
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Adenosine receptor A1 and Adenosine receptor A2b ligand (2,5-d... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiest... 7 0
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Adenosine receptor A2b and Adenosine receptor A2a ligand 1-eth... 5 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Glycogen synthase kinase-3 beta and G1/S-specific cyclin-E2 in... 2 0
Putative NP ZINC40310254 Family 74 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00424453 CHEMBL245649 Bioactive SureCN4813844
CFAMM00424452 CHEMBL245648 Bioactive N-[4-[[8-[(6,7-dimethoxyisoquinolin-4-yl)methyl]-1-methyl-2,6-dioxo-7H-purin-3-yl]methyl]phenyl]propane-2-sulfonamide
CFAMM00424458 CHEMBL246470 Bioactive SureCN3054648
CFAMM00424465 CHEMBL393440 Bioactive 8-[(6,7-dimethoxyisoquinolin-4-yl)methyl]-3-(3-hydroxy-2-methylpropyl)-1-methyl-7H-purine-2,6-dione
CFAMM00424464 CHEMBL245841 Bioactive 8-[(6,7-dimethoxyisoquinolin-4-yl)methyl]-3-(2,2-dimethylpropyl)-1-methyl-7H-purine-2,6-dione
CFAMM00424455 CHEMBL247065 Bioactive 8-[(6,7-dimethoxyisoquinolin-4-yl)methyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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