CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13822
Family Name Histamine H3 receptor and Sodium-dependent serotonin transporter ligand AGN-PC-04UFVL family
No. of Seeds 3 No. of Other Members 6
Family Centroid CFAMM00424471 Functional Category Bioactive
Superfamily Lanosterol synthase and Carbonic anhydrase 9 Binder Superfamily
Class Class 2292

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Substance-P receptor Ligand Ezlopitant Family 10 207
D(3) dopamine receptor Ligand U-99194A Family 7 33
Vernakalant family 1 1
Acolbifene family 10 115
Dapoxetine family 3 40
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Sodium- and chloride-dependent GABA transporter 3 Inhibitor SN... 1 4
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Histamine H3 receptor Ligand 4-isopropyl-2-(phenoxymethyl)morp... 4 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Histamine H3 receptor Ligand 1-(3-(2-(3-methoxyphenoxy)ethoxy)... 3 9
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Tyrosinase Inhibitor 1-(3-phenoxypropyl)-4-(piperidin-1-yl)pip... 2 13
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 7 0
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 7 4
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Estrogen receptor and Estrogen receptor beta ligand (2R,3R,4S)... 3 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 4
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-(4-methoxyphenox... 2 1
Transporter and 5-hydroxytryptamine receptor 2C ligand CHEMBL1... 5 5
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-(4-... 2 6
Histamine H3 receptor ligand SureCN6071181 family 2 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... 3 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-073OMG... 3 0
Sigma non-opioid intracellular receptor 1 ligand 4-[[1-[(2-bro... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Histamine H3 receptor and Sodium-dependent serotonin transport... 1 0
Vesicular acetylcholine transporter inhibitor (2R,3R)-5-(3-flu... 2 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-078ZCU... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 2
Histamine H3 receptor and Histamine H1 receptor ligand (NE)-N-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00424471 CHEMBL245921 Bioactive AGN-PC-04UFVL
CFAMM00424467 CHEMBL391193 Bioactive AGN-PC-04UFVH

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27746 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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