CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13827
Family Name Serine/threonine-protein kinase Chk1 inhibitor SureCN4806204 family
No. of Seeds 13 No. of Other Members 7
Family Centroid CFAMM00424512 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase Chk1 and Aurora kinase B Binder Superfamily
Class Class 5013

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
PF-02545920 family 16 140
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[6-[[... 1 0
Serine/threonine-protein kinase Chk1 inhibitor 4-[4-[6-[(4-hyd... 5 4
Serine/threonine-protein kinase Chk1 inhibitor SureCN6792758 f... 22 12
Serine/threonine-protein kinase Chk1 inhibitor SureCN6787304 f... 18 2
Serine/threonine-protein kinase Chk1 inhibitor SureCN4814441 f... 4 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN4817112 f... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN6784084 f... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN6217661 f... 2 0
Serine/threonine-protein kinase Chk1 and Aurora kinase B inhib... 14 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 3 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 2 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
RAC-alpha serine/threonine-protein kinase and Rho-associated p... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00424513 CHEMBL248871 Bioactive SureCN6789069
CFAMM00424527 CHEMBL398750 Bioactive SureCN4815954
CFAMM00424519 CHEMBL247824 Bioactive SureCN6789115
CFAMM00424512 CHEMBL248870 Bioactive SureCN4806204
CFAMM00424518 CHEMBL400796 Bioactive SureCN4816129
CFAMM00424525 CHEMBL399254 Bioactive 3-(6-chloropyridin-3-yl)-6,7-dimethoxy-1,4-dihydroindeno[1,2-c]pyrazole
CFAMM00424517 CHEMBL563792 Bioactive 7-ethyl-6-(oxolan-3-yloxy)-3-pyridin-3-yl-1,4-dihydroindeno[1,2-c]pyrazole
CFAMM00424509 CHEMBL245802 Bioactive 4-[(5Z)-5-(6,7-dimethoxy-2,4-dihydro-1H-indeno[1,2-c]pyrazol-3-ylidene)pyridin-2-ylidene]cyclohexa-2,5-dien-1-one
CFAMM00424516 CHEMBL400665 Bioactive SureCN6789032
CFAMM00424530 CHEMBL248680 Bioactive SureCN6789556
CFAMM00424522 CHEMBL247193 Bioactive SureCN4808699
CFAMM00424528 CHEMBL400744 Bioactive SureCN4817404
CFAMM00424514 CHEMBL247026 Bioactive 3-(6-fluoropyridin-3-yl)-6,7-dimethoxy-1,4-dihydroindeno[1,2-c]pyrazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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