CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
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CFam Family Information

CFAM Family ID CFFBM13836
Family Name Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349 family
No. of Seeds 2 No. of Other Members 14
Family Centroid CFAMM00150234 Functional Category Bioactive with Natural Product
Superfamily ARN-509 Superfamily
Class Class 295

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
HIV protease Inhibitor Saquinavir Family 64 428
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Delavirdine Family 1 68
Reverse transcriptase Inhibitor Nevirapine Family 23 640
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
26S proteasome Inhibitor Bortezomib Family 7 65
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Prothrombin Inhibitor Dabigatran Family 7 182
Transient receptor potential cation channel subfamily V member... 15 158
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Purine nucleoside phosphorylase Inhibitor BCX-34 Family 2 31
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Substance-P receptor Ligand GSK424887 Family 8 184
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Coagulation factor X Inhibitor Otamixaban Family 9 21
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Substance-P receptor Ligand TAK-637 Family 18 63
BIBT986 family 7 96
Amg 423 family 7 47
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
PHA848125 family 13 138
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CP-18770 family 6 27
JAK Inhibitor Momelotinib Family 33 83
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Arachidonate 5-lipoxygenase Inhibitor Ici 207968 Family 3 7
Class II cytokine receptor Ligand IL-10 Family 7 45
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-chlorophenyl)-5-... 2 8
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Cannabinoid receptor 2 Ligand JWH-249 Family 7 13
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 4 33
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 1 Ligand N-(2-phenylpropyl)qui... 3 1
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Cathepsin K inhibitor [(3S)-1-(1H-indole-6-carbonyl)-4,4-dimet... 2 4
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-[4... 4 0
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07ZA4D family 1 0
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10
Calcitonin gene-related peptide type 1 receptor ligand CHEMBL1... 5 8
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 4
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Cholecystokinin receptor type A ligand A-65186 family 2 6
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Smoothened homolog inhibitor SureCN1091571 family 2 2
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Transient receptor potential cation channel subfamily V member... 1 4
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Serine/threonine-protein kinase pim-3 and Serine/threonine-pro... 4 6
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Adenosine receptor A2a ligand AGN-PC-01LVXW family 2 25
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M4U... 4 5
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... 3 1
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Gonadotropin-releasing hormone receptor ligand AGN-PC-075KV1 f... 4 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Prelamin-A/C and Tyrosyl-DNA phosphodiesterase 1 inhibitor nif... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 1
Prelamin-A/C and Pyruvate kinase PKM inhibitor CHEMBL1481187 f... 1 7
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Cellular tumor antigen p53 inhibitor CHEMBL1551403 family 1 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Serine/threonine-protein kinase D3 and Protein kinase C delta ... 3 0
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Substance-K receptor ligand N-[1-[[(2S)-1-[[1-(oxan-4-ylmethyl... 3 0
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Cannabinoid receptor 2 ligand AGN-PC-0A9SMV family 1 1
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801305 ... 2 0
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... 5 0
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Cannabinoid receptor 2 ligand 1-[[4-[5-fluoro-6-(piperidin-1-y... 21 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 1
Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyr... 3 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 12
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 7 0
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935258 family 7 2
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Delta-type opioid receptor and Potassium voltage-gated channel... 2 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 14 1
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 7 1
Serine/threonine-protein kinase PLK1 and MAP kinase-activated ... 1 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Adenosine receptor A2b and Adenosine receptor A2a ligand N-(4-... 2 14
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 1 0
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Substance-P receptor ligand Netupitant family 5 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 6 6
Melanin-concentrating hormone receptor 1 ligand N-[(3S)-1-[[(3... 2 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 2 0
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
ALK tyrosine kinase receptor ligand N-[6-[[4-(2-hydroxypropan-... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
RAC-beta serine/threonine-protein kinase inhibitor SureCN57283... 2 0
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(meth... 1 1
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(tria... 1 0
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 2 0
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Translocator protein inhibitor CHEMBL2331870 family 2 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 3 4
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Gonadotropin-releasing hormone receptor ligand 6-[(4-chloro-2-... 3 3
Motilin receptor ligand SureCN2768052 family 3 0
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Leucine-rich repeat serine/threonine-protein kinase 2 and Vasc... 3 3
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 7 7
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 2 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 18
Disintegrin and metalloproteinase domain-containing protein 17... 10 4
C-C chemokine receptor type 2 ligand SureCN5947024 family 11 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 4 11
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Dipeptidyl peptidase 4 inhibitor 2-(3-aminopiperidin-1-yl)-3-b... 4 1
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 1
Hepatocyte growth factor receptor and Protein-tyrosine kinase ... 2 15
Proteinase-activated receptor 1 and Prothrombin ligand (2S)-N-... 3 23
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Endothelin-1 receptor and Endothelin B receptor ligand 2-[[(2R... 5 3
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... 3 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Histone deacetylase 1 inhibitor AGN-PC-0456JP family 1 0
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 5 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 1 0
KiSS-1 receptor ligand SureCN5132924 family 2 4
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[4-oxo-3-(4-p... 2 1
72 kDa type IV collagenase and Interstitial collagenase inhibi... 1 1
KiSS-1 receptor ligand N-[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-... 1 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Cytochrome P450 2C9 inhibitor AGN-PC-04XDND family 1 3
Adenosine receptor A2b and Adenosine receptor A1 ligand [4-(2,... 6 15
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 0
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN4964150 ... 3 0
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
Egl nine homolog 1 inhibitor 2-[(1,6-diphenylimidazo[4,5-c]pyr... 1 5
Melanin-concentrating hormone receptor 1 ligand SureCN4917950 ... 3 5
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07B2Q... 6 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
Heat shock protein HSP 90-alpha inhibitor CHEMBL1760611 family 19 25
Glucocorticoid receptor ligand 5-[(6-methylpyridin-2-yl)methyl... 3 0
Methionine aminopeptidase 1 inhibitor ethyl 4-[4-(2-pyridin-2-... 2 3
Metabotropic glutamate receptor 5 ligand 3-methyl-1-[2-[3-(tri... 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Histone deacetylase 1 inhibitor SureCN4538615 family 2 2
Protein-glutamine gamma-glutamyltransferase 2 inhibitor SureCN... 2 2
Potassium voltage-gated channel subfamily A member 5 ligand 3-... 1 0
Histone deacetylase 1 inhibitor N-[(2S)-1,8-dioxo-1-[2-(2-phen... 2 0
Tyrosine-protein kinase JAK3 inhibitor (3Z)-5-pyridin-3-yl-3-(... 1 0
Proto-oncogene Wnt-3 inhibitor CHEMBL563202 family 2 0
9H-pyrido[3,4-b]indole-3-carboxamide NP (1-(3-bromophenyl)-9h-... 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00424562 CHEMBL57047 Bioactive 1-[2-[4-[(5-fluoro-1H-indol-3-yl)methyl]piperidin-1-yl]ethyl]-3-methylquinazoline-2,4-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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