CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13841
Family Name Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-carbonylamino)-N-quinolin-6-yloctanediamide family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00424607 Functional Category Bioactive
Superfamily Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoylamino)hexanamide Superfamily
Class Class 147

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
Reverse transcriptase Inhibitor Nevirapine Family 23 640
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
26S proteasome Inhibitor Bortezomib Family 7 65
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Prothrombin Inhibitor Dabigatran Family 7 182
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Substance-P receptor Ligand GSK424887 Family 8 184
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Coagulation factor X Inhibitor Otamixaban Family 9 21
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Substance-P receptor Ligand TAK-637 Family 18 63
Histone deacetylase 1 Inhibitor Pyroxamide Family 4 13
Setipiprant family 5 118
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CP-18770 family 6 27
JAK Inhibitor Momelotinib Family 33 83
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-chlorophenyl)-5-... 2 8
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
MO15-related protein kinase Pfmrk Inhibitor (e)-1-(4-nitro-phe... 2 9
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 1 Ligand N-(2-phenylpropyl)qui... 3 1
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Histone deacetylase 3 and Histone deacetylase 6 inhibitor Tria... 20 37
Mitogen-activated protein kinase 14 and Mast/stem cell growth ... 4 4
Cholecystokinin receptor type A ligand A-65186 family 2 6
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Serine/threonine-protein kinase pim-3 and Serine/threonine-pro... 4 6
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 1
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Prelamin-A/C and Tyrosyl-DNA phosphodiesterase 1 inhibitor nif... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Disintegrin and metalloproteinase domain-containing protein 17... 3 3
Prelamin-A/C and Pyruvate kinase PKM inhibitor CHEMBL1481187 f... 1 7
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Peptide deformylase inhibitor (2R)-N-[(2S)-3,3-dimethyl-1-oxo-... 2 1
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Translocator protein inhibitor AGN-PC-08WI0V family 1 0
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Substance-K receptor ligand N-[1-[[(2S)-1-[[1-(oxan-4-ylmethyl... 3 0
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Histamine H3 receptor ligand SureCN1857507 family 1 4
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Delta-type opioid receptor and Potassium voltage-gated channel... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Serine/threonine-protein kinase PLK1 and MAP kinase-activated ... 1 2
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Melanin-concentrating hormone receptor 1 ligand N-[(3S)-1-[[(3... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Neuromedin-K receptor and Potassium voltage-gated channel subf... 13 2
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(meth... 1 1
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... 1 0
Seprase and Prolyl endopeptidase inhibitor [(2R)-1-[(2R)-2-[(2... 4 2
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 3 4
Motilin receptor ligand SureCN2768052 family 3 0
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
Metabotropic glutamate receptor 5 ligand AGN-PC-09SALK family 2 15
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... 3 1
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Histone deacetylase 1 inhibitor AGN-PC-0456JP family 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
KiSS-1 receptor ligand SureCN5132924 family 2 4
72 kDa type IV collagenase and Interstitial collagenase inhibi... 1 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
Cytochrome P450 2C9 inhibitor AGN-PC-04XDND family 1 3
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Dipeptidyl peptidase 4 inhibitor SureCN5777667 family 1 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-[3-(dimethylamino)... 106 49
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
P2Y purinoceptor 12 inhibitor (4S)-4-[(4,6-diphenylpyridine-2-... 1 0
Interstitial collagenase and Stromelysin-1 inhibitor CHEMBL887... 1 0
Methionine aminopeptidase 1 inhibitor ethyl 4-[4-(2-pyridin-2-... 2 3
Histone deacetylase 6 and Histone deacetylase 8 inhibitor N-hy... 1 0
Metabotropic glutamate receptor 5 ligand 3-methyl-1-[2-[3-(tri... 3 1
Neuromedin-K receptor ligand AGN-PC-00GCXP family 3 2
Tyrosine-protein kinase JAK3 inhibitor (3Z)-5-pyridin-3-yl-3-(... 1 0
Proto-oncogene Wnt-3 inhibitor CHEMBL563202 family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00424607 CHEMBL393060 Bioactive (2S)-N'-hydroxy-2-(pyridine-2-carbonylamino)-N-quinolin-6-yloctanediamide
CFAMM00424609 CHEMBL246189 Bioactive (2S)-2-benzamido-N'-hydroxy-N-quinolin-6-yloctanediamide
CFAMM00424608 CHEMBL391569 Bioactive (2S)-N'-hydroxy-2-(pyridine-2-carbonylamino)-N-quinolin-8-yloctanediamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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