CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13850
Family Name MAP kinase-activated protein kinase 2 inhibitor 2-[(4,4-dimethyl-1-oxo-2,3-dihydropyrazino[1,2-a]indole-7-carbonyl)amino]-N-(1-methylpiperidin-4-yl)-1,3-thiazole-4-carboxamide family
No. of Seeds 11 No. of Other Members 11
Family Centroid CFAMM00424710 Functional Category Bioactive
Superfamily Cathepsin B and Cathepsin K Inhibitor L-006235-1 Superfamily
Class Class 804

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Cathepsin B and Cathepsin K Inhibitor L-006235-1 Family 19 75
Mitogen-activated protein kinase 11 and Mitogen-activated prot... 10 31
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Cathepsin K inhibitor N-[1-[[(2S,3S)-2-ethyl-4-oxooxolan-3-yl]... 1 0
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Coagulation factor X and Prothrombin inhibitor SureCN763988 fa... 31 86
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
Prothrombin inhibitor (3R,6S,8aS)-N-[5-(diaminomethylideneamin... 2 3
Coagulation factor X inhibitor 2-[4-[(5-chloro-1H-indole-2-car... 4 0
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Cathepsin K and Cathepsin L1 inhibitor (2R)-N-(cyanomethyl)-4-... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 5 5
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
D(3) dopamine receptor ligand N-[4-[2-[[(6S)-2-amino-4,5,6,7-t... 4 1
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-N-[... 3 0
Metabotropic glutamate receptor 5 ligand 5-methyl-N-(4-methyl-... 1 2
Serine/threonine-protein kinase Chk1 inhibitor 2-(1,3-dihydroi... 2 5
Serine/threonine-protein kinase Chk1 inhibitor 2-indazol-1-yl-... 4 5
Glucocorticoid receptor ligand 3-(1H-indol-5-yl)-2,2-dimethyl-... 2 7
Coagulation factor X inhibitor N-[(1R,2S,5S)-2-[(5-bromo-1H-in... 1 1
Proto-oncogene tyrosine-protein kinase LCK and Tyrosine-protei... 3 9
Coagulation factor X inhibitor AGN-PC-09QNAS family 2 1
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-03LEDF family 3 4
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL246396 family 22 0
Nuclear receptor ROR-gamma and Prelamin-A/C ligand CHEMBL13846... 1 0
Coagulation factor X inhibitor 2,4-dimethyl-N-[N-(3-methylphen... 1 1


External ID

Functional Category

Molecule Name

CFAMM00424705 CHEMBL256196 Bioactive N-(1-ethylpiperidin-4-yl)-2-[(4-methyl-1-oxo-3,4-dihydro-2H-pyrazino[1,2-a]indole-7-carbonyl)amino]-1,3-thiazole-4-carboxamide
CFAMM00424718 CHEMBL403258 Bioactive N-(1-benzylpiperidin-4-yl)-2-[(1-oxospiro[2,3-dihydropyrazino[1,2-a]indole-4,1'-cyclobutane]-7-carbonyl)amino]-1,3-thiazole-4-carboxamide
CFAMM00424711 CHEMBL403154 Bioactive 2-[(4,4-dimethyl-1-oxo-2,3-dihydropyrazino[1,2-a]indole-7-carbonyl)amino]-N-[1-(2,2-dimethylpropyl)piperidin-4-yl]-1,3-thiazole-4-carboxamide
CFAMM00424710 CHEMBL270148 Bioactive 2-[(4,4-dimethyl-1-oxo-2,3-dihydropyrazino[1,2-a]indole-7-carbonyl)amino]-N-(1-methylpiperidin-4-yl)-1,3-thiazole-4-carboxamide
CFAMM00424709 CHEMBL429504 Bioactive N-(1-benzylpiperidin-4-yl)-2-[(4,4-dimethyl-1-oxo-2,3-dihydropyrazino[1,2-a]indole-7-carbonyl)amino]-1,3-thiazole-4-carboxamide
CFAMM00424722 CHEMBL271309 Bioactive 2-[(4-methyl-1-oxo-3,4-dihydro-2H-pyrazino[1,2-a]indole-7-carbonyl)amino]-N-(1-methylpiperidin-4-yl)-1,3-thiazole-4-carboxamide
CFAMM00424715 CHEMBL255991 Bioactive 2-[(4-methyl-1-oxo-3,4-dihydro-2H-pyrazino[1,2-a]indole-7-carbonyl)amino]-N-[1-(2-methylpropyl)piperidin-4-yl]-1,3-thiazole-4-carboxamide
CFAMM00424714 CHEMBL258045 Bioactive N-(1-methylpiperidin-4-yl)-2-[(1-oxospiro[2,3-dihydropyrazino[1,2-a]indole-4,1'-cyclobutane]-7-carbonyl)amino]-1,3-thiazole-4-carboxamide
CFAMM00424713 CHEMBL246301 Bioactive 2-[(4-methyl-1-oxo-2,3,4,9-tetrahydropyrido[3,4-b]indole-6-carbonyl)amino]-N-(1-methylpiperidin-4-yl)-1,3-thiazole-4-carboxamide
CFAMM00424706 CHEMBL256194 Bioactive N-[1-(2,2-dimethylpropyl)piperidin-4-yl]-2-[(4-methyl-1-oxo-3,4-dihydro-2H-pyrazino[1,2-a]indole-7-carbonyl)amino]-1,3-thiazole-4-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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