CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13854
Family Name Mast/stem cell growth factor receptor Kit and Serine/threonine-protein kinase B-raf ligand SureCN4945573 family
No. of Seeds 11 No. of Other Members 29
Family Centroid CFAMM00364946 Functional Category Bioactive with Natural Product
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Inhibitor Bay 80-6946 Superfamily
Class Class 850

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor GSK2... 15 18
MK-6096 family 3 69
Glucokinase Inhibitor GKA1 Family 2 67
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Glycogen synthase kinase-3 alpha and Casein kinase II subunit ... 1 16
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Melanin-concentrating hormone receptor 1 ligand N-[1-(1,3-benz... 2 5
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 1
Focal adhesion kinase 1 inhibitor AGN-PC-00AVK6 family 1 1
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a... 5 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Glycogen synthase kinase-3 beta inhibitor 3-imidazo[1,2-a]pyri... 1 1
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(1H-benzimidazole... 1 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 2 2
Mast/stem cell growth factor receptor Kit and Serine/threonine... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN4854955 f... 2 0
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 4 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2R ... 1 3
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
Macrophage colony-stimulating factor 1 receptor ligand 4-(3-ch... 5 4
Neuropeptide Y receptor type 5 ligand 1'-(5H-[1,3]dioxolo[4,5-... 2 1
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
Urotensin-2 receptor ligand 2-[(1R)-4-[(6-chloropyrazin-2-yl)a... 2 1
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 2 25
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor AGN-... 3 15
Mast/stem cell growth factor receptor Kit and RAC-alpha serine... 1 0
Dihydrofolate reductase inhibitor AGN-PC-073PP8 family 1 0
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00424757 CHEMBL248256 Bioactive SureCN4937889
CFAMM00424764 CHEMBL400109 Bioactive SureCN4944642
CFAMM00424755 CHEMBL398052 Bioactive SureCN14007917
CFAMM00424732 CHEMBL246424 Bioactive AGN-PC-00EC5A
CFAMM00424753 CHEMBL395700 Bioactive SureCN14007925

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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