CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13857
Family Name Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AGN-PC-015CTS family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00424778 Functional Category Bioactive
Superfamily Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 Binder Superfamily 4
Class Class 1334

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Transient receptor potential cation channel subfamily V member... 15 457
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CRA1000 Family 4 39
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Corticotropin-releasing factor receptor 1 Ligand N-mesityl-6-m... 3 2
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 8
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 4
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Cannabinoid receptor 2 ligand 2-tert-butyl-5-ethylsulfonyl-1-(... 28 32
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
Growth hormone secretagogue receptor type 1 ligand SureCN63605... 5 7
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 2-[4... 5 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Neuropeptide Y receptor type 5 and Cytochrome P450 1A2 ligand ... 8 19
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Cannabinoid receptor 2 ligand 4-[[2-tert-butyl-1-(cyclohexylme... 2 0
Cannabinoid receptor 2 ligand 4-[2-tert-butyl-1-(oxan-4-ylmeth... 5 0
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Dihydrofolate reductase inhibitor WR 158122 family 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 3
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 3 0
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 2 9
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 1 3
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 3 3
Prostaglandin G/H synthase 2 inhibitor AGN-PC-073UDQ family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00424780 CHEMBL246529 Bioactive AGN-PC-046QYV
CFAMM00424779 CHEMBL246530 Bioactive AGN-PC-014Z6Q
CFAMM00424778 CHEMBL428223 Bioactive AGN-PC-015CTS

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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