CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13875
Family Name Melanocortin receptor 4 ligand [(3R,4S)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidin-3-yl]-[4-[1-[[(4-methoxyphenyl)methylamino]methyl]cyclohexyl]piperazin-1-yl]methanone family
No. of Seeds 5 No. of Other Members 8
Family Centroid CFAMM00424873 Functional Category Bioactive
Superfamily Melanocortin receptor 4 and Mu-type opioid receptor Binder Superfamily 2
Class Class 1077

Cousin Family NamesSeedsMembers
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Histamine H1 receptor Ligand MDL-105212 Family 16 56
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Neuromedin-K receptor ligand AGN-PC-09QL9U family 1 3
Vasopressin V1a receptor ligand 1-(4-chlorophenyl)-N-[(2R)-1-[... 2 8
Mu-type opioid receptor ligand AGN-PC-075GAC family 16 8
Potassium voltage-gated channel subfamily H member 2 and Melan... 4 22
Bone morphogenetic protein 1 inhibitor benzyl N-[(4R)-4-[1,3-b... 6 25
Melanocortin receptor 4 and Melanocortin receptor 3 ligand N-[... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
Substance-P receptor ligand 1-[3-(3,4-dichlorophenyl)-3-[2-(1'... 5 4
Motilin receptor ligand N-[1-[(1-amino-1-oxo-4-phenylbutan-2-y... 4 3
Kappa-type opioid receptor ligand 2-(3,4-dichlorophenyl)-1-[(4... 7 1
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Melanocortin receptor 4 and Melanocortin receptor 5 ligand 3-a... 2 2
Renin inhibitor (1R,5S)-N-[(2-chlorophenyl)methyl]-7-[4-[3-[(2... 9 0
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07R5XZ family 2 2
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00424871 CHEMBL398929 Bioactive [(3R,4S)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidin-3-yl]-[4-[1-[[(3-fluoro-4-methoxyphenyl)methylamino]methyl]cyclohexyl]piperazin-1-yl]methanone
CFAMM00424863 CHEMBL249271 Bioactive [(3R,4S)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidin-3-yl]-[4-[1-[[(4-propan-2-yloxyphenyl)methylamino]methyl]cyclohexyl]piperazin-1-yl]methanone
CFAMM00424861 CHEMBL399766 Bioactive [4-[1-[(1,3-benzodioxol-5-ylmethylamino)methyl]cyclohexyl]piperazin-1-yl]-[(3R,4S)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidin-3-yl]methanone
CFAMM00424868 CHEMBL247010 Bioactive [(3R,4S)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidin-3-yl]-[4-[1-[[(2-fluoro-4-methoxyphenyl)methylamino]methyl]cyclohexyl]piperazin-1-yl]methanone
CFAMM00424873 CHEMBL401487 Bioactive [(3R,4S)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidin-3-yl]-[4-[1-[[(4-methoxyphenyl)methylamino]methyl]cyclohexyl]piperazin-1-yl]methanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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