CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13882
Family Name C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4-methylphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide family
No. of Seeds 5 No. of Other Members 1
Family Centroid CFAMM00424910 Functional Category Bioactive
Superfamily C-C chemokine receptor type 2 Binder Superfamily 3
Class Class 2844

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
DNA Binder Procarbazine Family 8 358
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Motilin receptor Ligand GSK962040 Family 30 457
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
Intedanib family 7 54
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Potassium voltage-gated channel subfamily A member 5 Ligand N-... 8 32
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 12 4
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Vasopressin V1a receptor ligand AGN-PC-074VJP family 3 1
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 6 3
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
Neutrophil elastase inhibitor 2-[3-(benzylsulfamoylamino)-2-ox... 5 27
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 0
Acetylcholinesterase inhibitor CHEMBL1651130 family 2 3
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 10 0
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 53
Hypoxia-inducible factor 1-alpha and Ubiquitin carboxyl-termin... 1 1
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 8 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
Lysine-specific histone demethylase 1A and Amine oxidase [flav... 2 1
C-C chemokine receptor type 2 ligand SureCN2983871 family 9 8
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
C-C chemokine receptor type 2 ligand N-[2-[[(2S,3S)-1-[(2,4-di... 13 8
C-C chemokine receptor type 2 ligand N-[3-amino-5-(trifluorome... 4 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 4
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 1 1
C-C chemokine receptor type 2 ligand 2-(cyclohexanecarbonylami... 1 0
C-C chemokine receptor type 2 ligand AGN-PC-03L0X5 family 13 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 7 12
Growth hormone secretagogue receptor type 1 ligand SureCN77944... 1 2
Prothrombin inhibitor N-[7-amino-1-[2-(4-carbamoylphenyl)ethyl... 8 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Beta-secretase 1 and Beta-secretase 2 inhibitor AC1N6ZLA family 1 0
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
Glycogen phosphorylase, liver form inhibitor SureCN5195475 family 9 5
C-C chemokine receptor type 2 ligand AGN-PC-03L0Z6 family 1 1
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(1-hydroxy-3... 3 0
Neutrophil elastase inhibitor 1-[(2S)-3-methyl-2-[(4-nitrobenz... 1 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 4 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Tyrosine-protein kinase ITK/TSK and Mast/stem cell growth fact... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Serine/threonine-protein kinase Chk1 inhibitor 6-oxo-9-(2-oxo-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00424913 CHEMBL257066 Bioactive 2-amino-N-[2-[[(3R)-1-[(4-ethenylphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
CFAMM00424911 CHEMBL271288 Bioactive 2-amino-N-[2-[[(3R)-1-[(4-ethylphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
CFAMM00424910 CHEMBL271290 Bioactive 2-amino-N-[2-[[(3R)-1-[(4-methylphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
CFAMM00424909 CHEMBL271725 Bioactive 2-amino-N-[2-[[(3R)-1-[(3-amino-4-methylphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27518 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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