CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1390
Family Name Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhibitor (E)-3-(3,4-dihydroxyphenyl)-N-phenylprop-2-enamide family
No. of Seeds 5 No. of Other Members 3
Family Centroid CFAMM00322905 Functional Category Bioactive
Superfamily Matrix metalloproteinase-9 and 72 kDa type IV collagenase Binder Superfamily 2
Class Class 3359

Cousin Family NamesSeedsMembers
Cyclooxygenase Inhibitor Acetaminophen Family 2 42
Histamine H1 receptor Ligand Tranilast Family 5 125
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Oestrogen receptor and Estrogen receptor beta Ligand 2-(4-hydr... 10 17
High affinity nerve growth factor receptor and RAF proto-oncog... 3 29
Oestrogen receptor and Estrogen receptor beta Ligand 4-bromo-2... 3 0
Apoptosis regulator Bcl-2 Inhibitor N-phenyl-2,3,4-trihydroxy-... 3 11
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 7 18
Macrophage migration inhibitory factor Inhibitor 2-(4-hydroxys... 8 19
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 3 8
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 4 2
Carbonic anhydrase 12 and Carbonic anhydrase 2 inhibitor (E)-2... 5 6
Testosterone 17-beta-dehydrogenase 3 inhibitor (5Z)-5-[(3-brom... 2 12
Amyloid beta A4 protein inhibitor SureCN6372684 family 2 7
Carbonic anhydrase 9 and Carbonic anhydrase 12 inhibitor (E)-2... 2 1
Sphingosine 1-phosphate receptor 3 and Sphingosine 1-phosphate... 3 9
NS3 inhibitor AGN-PC-074L2C family 1 3
Amino Acids and Derivatives Metabolite 5-Hydroxy-N-formylkynur... 3 3
Benzamides Metabolite 2-(Ethylamino)-4,5-dihydroxybenzamide Fa... 1 0


External ID

Functional Category

Molecule Name

CFAMM00322906 CHEMBL1165574 Bioactive (E)-3-(3,4-dihydroxyphenyl)-N-(2-fluorophenyl)prop-2-enamide
CFAMM00322905 CHEMBL275362 Bioactive (E)-3-(3,4-dihydroxyphenyl)-N-phenylprop-2-enamide
CFAMM00322904 CHEMBL1163444 Bioactive (E)-3-(3,4-dihydroxyphenyl)-N-(4-fluorophenyl)prop-2-enamide
CFAMM00322901 CHEMBL228097 Bioactive STK072711
CFAMM00322908 CHEMBL1165106 Bioactive (E)-3-(3,4-dihydroxyphenyl)-N-(4-methylphenyl)prop-2-enamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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