CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13905
Family Name Collagenase 3 inhibitor 5-[4-[4-(1H-benzimidazol-2-yl)phenoxy]phenoxy]-5-(2-ethoxyethyl)-1,3-diazinane-2,4,6-trione family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00425053 Functional Category Bioactive
Superfamily Collagenase 3 Binder Superfamily
Class Class 4655

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Adenosine receptor A2a Ligand KW-6002 Family 18 195
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Adenosine receptor A1 and Adenosine receptor A2b ligand 3-meth... 7 19
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-[4-[... 12 15
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 9 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Adenosine receptor A1 and Adenosine receptor A3 ligand SureCN5... 3 1
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 4 4
Adenosine receptor A2b ligand 2-[5-(2,6-dioxo-1,3-dipropyl-7H-... 1 0
Histamine H4 receptor ligand AGN-PC-00FEQJ family 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Angiopoietin-1 receptor and Vascular endothelial growth factor... 2 0
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Adenosine receptor A1 and Adenosine receptor A2b ligand (2,5-d... 2 0
Sterol O-acyltransferase 1 inhibitor 1-[4-[2-(4,5-diphenyl-1H-... 1 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Adenosine receptor A2b and Adenosine receptor A1 ligand N-(3,4... 1 8
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Adenosine receptor A2b and Adenosine receptor A2a ligand 1-eth... 5 2
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Adenosine receptor A1 and Adenosine receptor A2b ligand N-[2-[... 2 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Lysosomal Pro-X carboxypeptidase inhibitor 4-[6-[(2S)-2-(5,6-d... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00425053 CHEMBL248543 Bioactive 5-[4-[4-(1H-benzimidazol-2-yl)phenoxy]phenoxy]-5-(2-ethoxyethyl)-1,3-diazinane-2,4,6-trione
CFAMM00425056 CHEMBL250554 Bioactive 5-(2-ethoxyethyl)-5-[4-[4-(6-fluoro-1H-benzimidazol-2-yl)phenoxy]phenoxy]-1,3-diazinane-2,4,6-trione
CFAMM00425055 CHEMBL248939 Bioactive 5-[4-[4-(6-chloro-1H-benzimidazol-2-yl)phenoxy]phenoxy]-5-(2-ethoxyethyl)-1,3-diazinane-2,4,6-trione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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