CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13906
Family Name Substance-P receptor ligand 1-[(3S,4R)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)pyrrolidin-1-yl]ethanone family
No. of Seeds 9 No. of Other Members 0
Family Centroid CFAMM00425061 Functional Category Bioactive
Superfamily Substance-P receptor and Substance-K receptor Binder Superfamily
Class Class 3228

Cousin Family NamesSeedsMembers
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Substance-P receptor Ligand L-733060 Family 19 71
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
Substance-P receptor Ligand SCH-388714 Family 26 8
Substance-P receptor ligand (1S,2R)-2-[(1R)-1-[3,5-bis(trifluo... 12 0
Substance-P receptor ligand (1S,2R,5aS,7R,8aR,8bS)-2-[(1R)-1-[... 11 15
Substance-P receptor ligand (1S,2R)-2-[(1R)-1-[3,5-bis(trifluo... 2 0
Melanocortin receptor 4 and Melanocortin receptor 3 ligand Sur... 6 53
C-C chemokine receptor type 5 ligand N-[1-[[(3S,4R)-1-(cyclope... 1 16
Substance-P receptor ligand 1-[4-[[3,5-bis(trifluoromethyl)phe... 5 8
Substance-P receptor and Potassium voltage-gated channel subfa... 10 0
Substance-P receptor ligand 1-[[(1R,2R,3S)-3-[[3,5-bis(trifluo... 4 3
Substance-P receptor ligand 1-[(1R,2S,3S)-3-[[3,5-bis(trifluor... 7 2
Substance-P receptor ligand 2-[[(1R,2S,3S)-3-[(1R)-1-[3,5-bis(... 5 0
Substance-P receptor ligand 1-[3-[[(1R)-1-[3,5-bis(trifluorome... 2 0
Substance-P receptor ligand 2-[[(1R,2S,3S)-3-[[3,5-bis(trifluo... 6 0
Substance-P receptor ligand (5R)-5-[[[(1R,2S,3S)-3-[(1R)-1-[3,... 6 0
Substance-P receptor ligand (1R,2S,3S)-3-[(1R)-1-[3,5-bis(trif... 8 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 5 1
Substance-P receptor ligand (5S)-5-[(3S,4R)-3-[(1R)-1-[3,5-bis... 3 0
Substance-P receptor ligand methyl 2-[(2S,3S)-2-[[3,5-bis(trif... 1 1
Substance-P receptor ligand N-[(3S,5S)-5-[[(1R)-1-[3,5-bis(tri... 10 0
Substance-P receptor ligand (3aR,4R,5S,7aS)-5-[(1R)-1-[3,5-bis... 4 0
Melanin-concentrating hormone receptor 1 and Alpha-1A adrenerg... 1 0
Putative NP ZINC04026324 Family 6 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00425061 CHEMBL249145 Bioactive 1-[(3S,4R)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)pyrrolidin-1-yl]ethanone
CFAMM00425060 CHEMBL400848 Bioactive 1-[4-[(3S,4R)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)pyrrolidine-1-carbonyl]piperidin-1-yl]ethanone
CFAMM00425066 CHEMBL404855 Bioactive 1-[(3S,4R)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)pyrrolidin-1-yl]-2-methylpropan-1-one
CFAMM00425059 CHEMBL248545 Bioactive 1-[(3S,4R)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-phenylpyrrolidin-1-yl]-2,2-dimethylpropan-1-one
CFAMM00425065 CHEMBL400060 Bioactive 1-[4-[(3S,4R)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)pyrrolidine-1-carbonyl]piperazin-1-yl]ethanone
CFAMM00425058 CHEMBL251577 Bioactive 1-[(3S,4R)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)pyrrolidin-1-yl]propan-1-one
CFAMM00425064 CHEMBL249143 Bioactive (3S,4R)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)pyrrolidine-1-carbaldehyde
CFAMM00425063 CHEMBL399466 Bioactive [(3S,4R)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-phenylpyrrolidin-1-yl]-morpholin-4-ylmethanone
CFAMM00425062 CHEMBL249144 Bioactive 1-[(3S,4R)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-phenylpyrrolidin-1-yl]ethanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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