CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13915
Family Name Serine/threonine-protein kinase Chk1 and Aurora kinase B inhibitor Kinome_2117 family
No. of Seeds 14 No. of Other Members 0
Family Centroid CFAMM00258313 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase Chk1 and Aurora kinase B Binder Superfamily
Class Class 5013

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
PF-02545920 family 16 140
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
D(2) dopamine receptor Ligand SLV-314 Family 19 69
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Sigma non-opioid intracellular receptor 1 ligand 1'-butyl-6-me... 23 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 9 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Sigma non-opioid intracellular receptor 1 ligand 6-methoxy-1'-... 2 0
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand Piper... 3 14
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[6-[[... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN6792758 f... 22 12
Serine/threonine-protein kinase Chk1 inhibitor SureCN6787304 f... 18 2
Serine/threonine-protein kinase Chk1 inhibitor SureCN4806204 f... 13 7
Serine/threonine-protein kinase Chk1 inhibitor SureCN4814441 f... 4 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN4817112 f... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN6784084 f... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN6217661 f... 2 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 3 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
RAC-alpha serine/threonine-protein kinase and Rho-associated p... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00425146 CHEMBL249324 Bioactive 5-[6-(3-morpholin-4-ylpropoxy)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]pyridine-2-carbonitrile
CFAMM00425139 CHEMBL401177 Bioactive 5-[7-[3-[(2R,6S)-2,6-dimethylmorpholin-4-yl]propoxy]-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]pyridine-2-carbonitrile
CFAMM00425145 CHEMBL398754 Bioactive 5-[7-[3-(4-methylpiperazin-1-yl)propoxy]-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]pyridine-2-carbonitrile
CFAMM00425138 CHEMBL400570 Bioactive 5-[6-(2-morpholin-4-ylethoxy)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]pyridine-2-carbonitrile
CFAMM00425144 CHEMBL249114 Bioactive 5-[7-(5-morpholin-4-ylpentoxy)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]pyridine-2-carbonitrile
CFAMM00425137 CHEMBL248910 Bioactive 5-[7-(3-piperidin-4-ylpropoxy)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]pyridine-2-carbonitrile
CFAMM00425143 CHEMBL249283 Bioactive 5-[7-[4-(4-acetylpiperazin-1-yl)butoxy]-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]pyridine-2-carbonitrile
CFAMM00425136 CHEMBL248911 Bioactive Chk1_156
CFAMM00425142 CHEMBL563331 Bioactive 5-[6-(oxan-4-yloxy)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]pyridine-2-carbonitrile
CFAMM00425135 CHEMBL248720 Bioactive 5-[7-(3-piperidin-1-ylpropoxy)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]pyridine-2-carbonitrile
CFAMM00425141 CHEMBL248719 Bioactive 5-[7-[3-(1,4-oxazepan-4-yl)propoxy]-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]pyridine-2-carbonitrile
CFAMM00425140 CHEMBL400797 Bioactive 5-[7-[2-(2-morpholin-4-ylethoxy)ethoxy]-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]pyridine-2-carbonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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