CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13918
Family Name Transient receptor potential cation channel subfamily V member 1 ligand 1-isoquinolin-5-yl-3-[6-methoxy-1-[(4-methoxyphenyl)methyl]-1,2,3,4-tetrahydronaphthalen-2-yl]urea family
No. of Seeds 6 No. of Other Members 1
Family Centroid CFAMM00425159 Functional Category Bioactive
Superfamily Bifunctional epoxide hydrolase 2 and Transient receptor potential cation channel subfamily V member 1 Binder Superfamily
Class Class 2472

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Tivozanib family 4 6
Apricoxib family 8 77
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Cyclin-dependent kinase 4 Inhibitor 1-(7-hydroxy-naphthalen-1-... 2 1
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Transient receptor potential cation channel subfamily V member... 2 12
C-C chemokine receptor type 5 ligand (2,4-dimethyl-1-oxidopyri... 5 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Histamine H3 receptor and Cytochrome P450 3A4 ligand SureCN822... 3 7
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Prothrombin inhibitor AGN-PC-073H0Z family 9 6
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
P2Y purinoceptor 1 inhibitor 1-(4-tert-butylphenyl)-3-[2-(2-pr... 4 14
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Egl nine homolog 1 inhibitor 2-(2-methoxy-4-phenylphenyl)-8-[(... 1 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Neuropeptide Y receptor type 5 ligand AGN-PC-040NYD family 3 7
Vascular endothelial growth factor receptor 2 and Tyrosine-pro... 4 0
Vascular endothelial growth factor receptor 2 and Platelet-der... 1 0
Mitogen-activated protein kinase 9 and Tyrosine-protein kinase... 2 6
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 4
Transient receptor potential cation channel subfamily V member... 3 2
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 4 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00425156 CHEMBL400312 Bioactive 1-[1-[(3-chlorophenyl)methyl]-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl]-3-isoquinolin-5-ylurea
CFAMM00425155 CHEMBL250368 Bioactive 1-isoquinolin-5-yl-3-[2-(4-methoxyphenyl)-3-phenylpropyl]urea
CFAMM00425154 CHEMBL250149 Bioactive SureCN1734226
CFAMM00425160 CHEMBL250593 Bioactive 1-[1-[(4-bromophenyl)methyl]-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl]-3-isoquinolin-5-ylurea
CFAMM00425159 CHEMBL248762 Bioactive 1-isoquinolin-5-yl-3-[6-methoxy-1-[(4-methoxyphenyl)methyl]-1,2,3,4-tetrahydronaphthalen-2-yl]urea
CFAMM00425158 CHEMBL436638 Bioactive AGN-PC-00FIJ3

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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