CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13923
Family Name Cyclin-dependent kinase 1 inhibitor N-[[5-[(3Z)-3-[4-(methoxymethyl)benzimidazol-2-ylidene]-1,2-dihydropyrazolo[3,4-b]pyridin-5-yl]pyridin-3-yl]methyl]propan-1-amine family
No. of Seeds 3 No. of Other Members 7
Family Centroid CFAMM00425176 Functional Category Bioactive
Superfamily Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase erbB-2 Binder Superfamily
Class Class 855

Cousin Family NamesSeedsMembers
Type-1 angiotensin II receptor Ligand Candesartan Family 3 75
Type-1 angiotensin II receptor Ligand Telmisartan Family 4 181
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
HER Inhibitor AC480 Family 4 67
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 3
Adenosine receptor A1 ligand AGN-PC-07PMLW family 6 4
Serine/threonine-protein kinase B-raf inhibitor SureCN3495829 ... 24 0
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14574... 1 2
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Serine/threonine-protein kinase mTOR inhibitor SureCN3776855 f... 1 0
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Protein kinase C zeta type and Cyclin-dependent kinase 2 inhib... 2 13
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Fibroblast growth factor receptor 1 and Vascular endothelial g... 5 0
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 1
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Tyrosine-protein kinase SYK and Cytochrome P450 2D6 inhibitor ... 3 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Type-1 angiotensin II receptor ligand 2-propyl-3-[[4-[2-(2H-te... 3 0
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 4
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... 4 0
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Protein kinase C zeta type and Cyclin-dependent kinase 2 inhib... 2 4
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 1 2
Thymidylate synthase inhibitor AGN-PC-003VK9 family 1 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00425176 CHEMBL400568 Bioactive N-[[5-[(3Z)-3-[4-(methoxymethyl)benzimidazol-2-ylidene]-1,2-dihydropyrazolo[3,4-b]pyridin-5-yl]pyridin-3-yl]methyl]propan-1-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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