CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13930
Family Name Serine/threonine-protein kinase Chk1 inhibitor 5-[7-(2-morpholin-4-ylethylamino)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]pyridine-2-carbonitrile family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00425213 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase Chk1 and Serine/threonine-protein kinase B-raf Binder Superfamily
Class Class 1666

Cousin Family NamesSeedsMembers
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
Protein kinase C theta type and Protein kinase C delta type in... 7 17
Protein kinase C theta type and Protein kinase C delta type in... 16 8
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 6
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 6
CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-flu... 6 1
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 10 2
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1


External ID

Functional Category

Molecule Name

CFAMM00425214 CHEMBL249323 Bioactive 5-[7-(4-morpholin-4-ylbutyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]pyridine-2-carbonitrile
CFAMM00425213 CHEMBL249115 Bioactive 5-[7-(2-morpholin-4-ylethylamino)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]pyridine-2-carbonitrile

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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