CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13932
Family Name Serine/threonine-protein kinase Chk1 inhibitor 5-[(2S)-3-amino-2-fluoropropyl]-7,8-dicyclohexyl-3-methyl-2H-pyrazolo[4,3-c]quinolin-4-one family
No. of Seeds 4 No. of Other Members 6
Family Centroid CFAMM00425225 Functional Category Bioactive
Superfamily Leucine-rich repeat serine/threonine-protein kinase 2 and Orexin receptor type 1 Binder Superfamily
Class Class 208

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Aurora kinase B and Aurora kinase C Inhibitor PHA-680632 Family 5 72
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 19 12
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 29
5-hydroxytryptamine receptor 3A ligand SureCN8035577 family 5 4
Serine/threonine-protein kinase 17A and Myosin light chain kin... 3 7
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 18
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 4 3
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 5
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
Serine/threonine-protein kinase Chk1 inhibitor PDK1 inhibitor,... 1 4
Serine/threonine-protein kinase D1 inhibitor 3-[5-[3-bromo-4-(... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00425222 CHEMBL250481 Bioactive 5-(3-aminopropyl)-7,8-dicyclohexyl-3-methyl-2H-pyrazolo[4,3-c]quinolin-4-one
CFAMM00425227 CHEMBL250032 Bioactive CHEMBL250032
CFAMM00425225 CHEMBL249177 Bioactive 5-[(2S)-3-amino-2-fluoropropyl]-7,8-dicyclohexyl-3-methyl-2H-pyrazolo[4,3-c]quinolin-4-one
CFAMM00425223 CHEMBL398612 Bioactive 5-[(2R)-3-amino-2-fluoropropyl]-7,8-dicyclohexyl-3-methyl-2H-pyrazolo[4,3-c]quinolin-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27702 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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