CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13949
Family Name Cathepsin K inhibitor SureCN4138062 family
No. of Seeds 7 No. of Other Members 0
Family Centroid CFAMM00394312 Functional Category Bioactive
Superfamily Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-fluorene-2,4-dione Superfamily
Class Class 144

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Translocator protein Inhibitor Emapunil Family 7 89
Adenosine receptor A1 Ligand SLV320 Family 6 79
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
GDC-0349 family 44 77
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A2b Ligand CVT-7124 Family 14 64
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A2a Ligand (e,e)-8-(4-phenylbutadien-1-yl)c... 11 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Prothrombin inhibitor SureCN5856722 family 3 16
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Metabotropic glutamate receptor 5 ligand SureCN3866791 family 2 10
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Rho-associated protein kinase 2 and Rho-associated protein kin... 4 9
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Aurora kinase B and Cyclin-dependent kinase 1 inhibitor 7-cycl... 3 16
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Adenosine receptor A2b ligand (8Z)-8-(6-oxopyridin-3-ylidene)-... 1 0
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 1 0
Aurora kinase B and Aurora kinase A inhibitor (2S)-1-[4-[[1-[(... 12 4
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-isoquinolin-1-y... 3 2
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 7 0
Cathepsin K inhibitor CHEMBL2163360 family 1 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206058 family 5 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... 2 1
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Bifunctional epoxide hydrolase 2 and Potassium voltage-gated c... 1 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00425280 CHEMBL488859 Bioactive AGN-PC-01ND4C
CFAMM00425282 CHEMBL528104 Bioactive AGN-PC-005O8G
CFAMM00425281 CHEMBL249759 Bioactive 6-[(5,5-dimethyl-2,4-dioxo-1,3-oxazolidin-3-yl)methyl]-7-(2,2-dimethylpropyl)pyrrolo[2,3-d]pyrimidine-2-carbonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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