CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13959
Family Name Receptor tyrosine-protein kinase erbB-2 and Epidermal growth factor receptor ligand AGN-PC-009FZY family
No. of Seeds 9 No. of Other Members 2
Family Centroid CFAMM00144116 Functional Category Bioactive
Superfamily Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Superfamily
Class Class 1049

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Epidermal growth factor receptor and Receptor tyrosine-protein... 9 65
Tyrosine-protein kinase SYK Inhibitor R788 Family 3 7
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Epidermal growth factor receptor and Receptor tyrosine-protein... 16 89
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
AP26113 family 16 90
SB1518 family 7 103
Varlitinib family 2 8
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Dual specificity mitogen-activated protein kinase kinase 1 inh... 10 54
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 6 47
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Epidermal growth factor receptor and Mitogen-activated protein... 5 19
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
Receptor tyrosine-protein kinase erbB-2 ligand 2-[2-[4-[3-chlo... 4 5
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Hepatocyte growth factor receptor and Vascular endothelial gro... 15 0
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Epidermal growth factor receptor ligand SureCN4454332 family 18 5
Aurora kinase A inhibitor SureCN4289024 family 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Receptor tyrosine-protein kinase erbB-2 ligand SureCN3374869 f... 4 8
Epidermal growth factor receptor ligand AGN-PC-078X8C family 10 8
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 0
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 1
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 2 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 4 24
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 10 4
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
1-acyl-sn-glycerol-3-phosphate acyltransferase beta inhibitor ... 1 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00425331 CHEMBL250130 Bioactive SureCN4475853
CFAMM00425330 CHEMBL250132 Bioactive SureCN4476802
CFAMM00425328 CHEMBL444619 Bioactive AGN-PC-075X0G
CFAMM00425332 CHEMBL518750 Bioactive AGN-PC-00E2UJ

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48716 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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