CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13983
Family Name cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(benzenesulfonyl)-4-(3-ethylanilino)quinoline-3-carboxamide family
No. of Seeds 5 No. of Other Members 5
Family Centroid CFAMM00425502 Functional Category Bioactive
Superfamily Smoothened homolog Inhibitor Vismodegib Superfamily
Class Class 718

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Smoothened homolog Inhibitor Vismodegib Family 1 19
Neuromedin-K receptor Ligand SB222200 Family 17 235
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
D(3) dopamine receptor Ligand SB-277011 Family 13 178
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 9 Ligand Vercirnon Family 1 1
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-chlorophenyl)-5-... 2 8
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Branched-chain-amino-acid aminotransferase, cytosolic Inhibito... 1 2
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33
5-hydroxytryptamine receptor 6 ligand N-[[(1R)-6-(3-fluorophen... 1 6
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Cellular tumor antigen p53 and Ferritin light chain inhibitor ... 1 2
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Prelamin-A/C and Pyruvate kinase PKM inhibitor CHEMBL1481187 f... 1 7
Neuromedin-K receptor ligand 3-methylsulfinyl-N-[(1S)-1-phenyl... 3 5
Hepatocyte growth factor receptor ligand N-(11-oxo-2-thiophen-... 1 1
Cathepsin L1 and Cathepsin S inhibitor N-[(2S)-4-methyl-1-oxo-... 2 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 7 0
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(meth... 1 1
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 11
Motilin receptor ligand SureCN2768052 family 3 0
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(benzen... 4 4
Hepatocyte growth factor receptor and Protein-tyrosine kinase ... 2 15
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 3
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Histone deacetylase 1 inhibitor AGN-PC-0456JP family 1 0
Coagulation factor X and Trypsin-1 inhibitor SureCN6166035 family 1 2
B1 bradykinin receptor ligand AGN-PC-00RZQU family 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-(3... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 1 0
Hepatocyte growth factor receptor ligand N-[2-(3-chlorophenyl)... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00425502 CHEMBL571594 Bioactive 6-(benzenesulfonyl)-4-(3-ethylanilino)quinoline-3-carboxamide
CFAMM00425495 CHEMBL569352 Bioactive 4-anilino-6-(benzenesulfonyl)quinoline-3-carboxamide
CFAMM00425500 CHEMBL250571 Bioactive cFMS Receptor Inhibitor III
CFAMM00425499 CHEMBL473560 Bioactive 4-(3-cyanoanilino)-8-methyl-6-methylsulfonylquinoline-3-carboxamide
CFAMM00425498 CHEMBL571386 Bioactive 6-(benzenesulfonyl)-4-(3-cyanoanilino)quinoline-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26841 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543