CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
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CFam Family Information

CFAM Family ID CFFBM13989
Family Name Cathepsin K and Cathepsin S inhibitor SureCN4138353 family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00182365 Functional Category Bioactive
Superfamily Alpha-1A adrenergic receptor Ligand A-315456 Superfamily
Class Class 2000

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Histamine H1 receptor Ligand Mizolastine Family 14 603
Mast/stem cell growth factor receptor Kit and Vascular endothe... 6 34
Prothrombin Inhibitor Dabigatran Family 7 182
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Transient receptor potential cation channel subfamily V member... 6 66
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Adenosine receptor A1 Ligand SLV320 Family 6 79
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Aurora kinase B and Aurora kinase A Inhibitor PF-03814735 Family 2 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
SB989 family 17 91
GDC-0349 family 44 77
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
PF-4217903 family 14 65
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Tryptase Inhibitor Babim Family 12 90
Class II cytokine receptor Ligand IL-10 Family 7 45
D(4) dopamine receptor Ligand L-745,870 Family 30 205
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Herpes simplex virus type 1 thymidine kinase Inhibitor 9-(4-hy... 2 13
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 4 33
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Glycogen synthase kinase-3 beta Inhibitor N-(8-(3-cyanophenyl)... 1 0
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Adenosine kinase inhibitor GP683 family 12 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Prothrombin inhibitor SureCN5855286 family 15 8
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5854779 family 4 9
Adenosine kinase inhibitor abt-702 family 14 1
Prothrombin inhibitor SureCN5856722 family 3 16
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 3
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 13 100
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 1 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 0
Histone deacetylase 1 and Histone deacetylase 8 inhibitor (E)-... 3 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
Platelet-activating factor receptor ligand 5-methyl-2-[4-(2-me... 1 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Mitogen-activated protein kinase 14 inhibitor (E)-3-(2,6-dichl... 1 1
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Gonadotropin-releasing hormone receptor ligand AGN-PC-075KV1 f... 4 1
Survival motor neuron protein and Menin inhibitor CHEMBL132797... 1 1
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
Prelamin-A/C and Lethal(3)malignant brain tumor-like protein 1... 1 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Dihydrofolate reductase inhibitor AC1LAKQL family 3 1
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Corticotropin-releasing factor receptor 1 ligand SureCN6301726... 4 1
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 1
Cannabinoid receptor 2 ligand AGN-PC-0A9SMV family 1 1
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 4 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 6 0
Glucose-dependent insulinotropic receptor ligand 4-({Ethyl-[1-... 6 12
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
ALK tyrosine kinase receptor and Insulin receptor ligand N-[(1... 3 6
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(1H-pyr... 2 8
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Casein kinase II subunit alpha inhibitor AGN-PC-0766PM family 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Vascular endothelial growth factor receptor 2 ligand urea deri... 3 9
Vascular endothelial growth factor receptor 2 ligand urea deri... 2 0
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Heat shock protein HSP 90-beta inhibitor N-[(9R)-4-(3H-imidazo... 1 0
Tyrosine-protein kinase JAK2 and ALK tyrosine kinase receptor ... 5 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Cyclin-dependent kinase 1 inhibitor 4-[[4-(3H-benzimidazol-5-y... 1 0
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[... 3 7
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 1 0
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Transient receptor potential cation channel subfamily V member... 4 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Renin inhibitor AGN-PC-073MLF family 7 6
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 7 0
Cathepsin K inhibitor CHEMBL2163360 family 1 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 4 8
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206058 family 5 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Serine/threonine-protein kinase TBK1 and 3-phosphoinositide-de... 3 3
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Tyrosine-protein kinase ABL1 and Abelson tyrosine-protein kina... 3 0
Serine/threonine-protein kinase ATR and Serine/threonine-prote... 8 10
Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... 2 1
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
Translocator protein inhibitor CHEMBL2331870 family 2 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 5
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 1
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 1 2
Mast/stem cell growth factor receptor Kit and Proto-oncogene t... 3 5
Proto-oncogene tyrosine-protein kinase Src and Mast/stem cell ... 4 1
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 9 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Cathepsin K inhibitor SureCN4141224 family 3 0
Cathepsin K inhibitor SureCN4138062 family 7 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 5
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Cathepsin K inhibitor 4-[2,2-dimethylpropyl-[[4-(1,2,4-triazol... 2 1
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Glycogen synthase kinase-3 beta inhibitor GSK-3beta Inhibitor ... 1 0
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 22
Epidermal growth factor receptor ligand Pyrroloquinazoline der... 7 0
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 3
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 4 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
Type-1 angiotensin II receptor ligand SureCN7390271 family 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 1 0
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... 4 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 3
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Mitogen-activated protein kinase 8 inhibitor N-[4-[4-[2-(cyclo... 1 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 11 1
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 5 0
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Transient receptor potential cation channel subfamily V member... 3 2
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Gonadotropin-releasing hormone receptor ligand AGN-PC-00AWCA f... 1 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
Bifunctional epoxide hydrolase 2 and Potassium voltage-gated c... 1 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-[3-(2-hydroxyeth... 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NS1A family 7 0
Tyrosine-protein kinase ZAP-70 inhibitor AGN-PC-07CO7Z family 1 0
C-C chemokine receptor type 5 ligand AC1MHPAK family 5 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 9 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Cyclooxygenase 2 and Prostaglandin G/H synthase 1 inhibitor Su... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27075 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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