CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14006
Family Name High affinity nerve growth factor receptor and Hepatocyte growth factor receptor ligand 2-amino-1-[4-[5-[[2-[(6-bromopyridin-2-yl)amino]-1,3-thiazol-5-yl]sulfanyl]-2-methylbenzoyl]piperazin-1-yl]ethanone family
No. of Seeds 6 No. of Other Members 8
Family Centroid CFAMM00425579 Functional Category Bioactive
Superfamily RAC-alpha serine/threonine-protein kinase and RAC-gamma serine/threonine-protein kinase Binder Superfamily
Class Class 3284

Cousin Family NamesSeedsMembers
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-02WPKX family 2 5
Vascular endothelial growth factor receptor 2 ligand AC1NS6KN ... 4 5
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Tyrosine-protein kinase Lck inhibitor AGN-PC-03HL8Q family 4 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
Tyrosine-protein kinase ABL1 inhibitor AGN-PC-04SU6B family 2 3
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-03LEDF family 3 4


External ID

Functional Category

Molecule Name

CFAMM00425572 CHEMBL254268 Bioactive 5-[[2-[(6-bromopyridin-2-yl)amino]-1,3-thiazol-5-yl]sulfanyl]-N-(2-cyanoethyl)-N,2-dimethylbenzamide
CFAMM00425571 CHEMBL254267 Bioactive 5-[[2-[(6-bromopyridin-2-yl)amino]-1,3-thiazol-5-yl]sulfanyl]-N-(cyanomethyl)-N,2-dimethylbenzamide
CFAMM00425576 CHEMBL254050 Bioactive 1-[4-[5-[[2-[(6-bromopyridin-2-yl)amino]-1,3-thiazol-5-yl]sulfanyl]-2-methylbenzoyl]piperazin-1-yl]ethanone
CFAMM00425568 CHEMBL251796 Bioactive (2R)-2-amino-1-[4-[5-[[2-[(6-bromopyridin-2-yl)amino]-1,3-thiazol-5-yl]sulfanyl]-2-methylbenzoyl]piperazin-1-yl]propan-1-one
CFAMM00425567 CHEMBL251795 Bioactive (2S)-2-amino-1-[4-[5-[[2-[(6-bromopyridin-2-yl)amino]-1,3-thiazol-5-yl]sulfanyl]-2-methylbenzoyl]piperazin-1-yl]propan-1-one
CFAMM00425579 CHEMBL254895 Bioactive 2-amino-1-[4-[5-[[2-[(6-bromopyridin-2-yl)amino]-1,3-thiazol-5-yl]sulfanyl]-2-methylbenzoyl]piperazin-1-yl]ethanone

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

Last update by



80838 visits since 2014 .........


Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

All rights reserved.

Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links


Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543