CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14009
Family Name Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhibitor (2S)-N-hydroxy-3-[N-methylsulfonyl-4-[4-(trifluoromethyl)phenoxy]anilino]-2-piperidin-1-ylpropanamide family
No. of Seeds 20 No. of Other Members 23
Family Centroid CFAMM00425637 Functional Category Bioactive
Superfamily Matrix metalloproteinase-9 and 72 kDa type IV collagenase Binder Superfamily 15
Class Class 1884

Cousin Family NamesSeedsMembers
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
Substance-K receptor Ligand MEN-14933 Family 13 154
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Fatty-acid amide hydrolase 1 Inhibitor Benzaldehyde O-4-ethoxy... 21 4
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Pol polyprotein inhibitor AC1LAGJO family 6 1
Neutrophil collagenase inhibitor (3R)-2-[4-[4-(dimethylamino)p... 2 4
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin S and Cathepsin K inhibitor SureCN3018173 family 2 4
Bone morphogenetic protein 1 inhibitor 3-[[4-(benzylcarbamoyla... 1 9
Histamine H3 receptor and Histamine receptor H3 ligand 1-[4-[3... 2 0
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 4 2
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 4 17
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 8 6
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-acety... 6 7
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00425600 CHEMBL399565 Bioactive (2S)-2-(4-fluoroanilino)-N-hydroxy-3-[4-(4-methylphenoxy)-N-methylsulfonylanilino]propanamide
CFAMM00425613 CHEMBL398644 Bioactive (2S)-N-hydroxy-2-(4-hydroxypiperidin-1-yl)-3-[N-methylsulfonyl-4-[4-(trifluoromethyl)phenoxy]anilino]propanamide
CFAMM00425626 CHEMBL429486 Bioactive (2S)-N-hydroxy-2-(4-methylsulfonylpiperazin-1-yl)-3-[N-methylsulfonyl-4-[4-(trifluoromethyl)phenoxy]anilino]propanamide
CFAMM00425606 CHEMBL429123 Bioactive (2S)-2-(1,1-dioxo-1,4-thiazinan-4-yl)-N-hydroxy-3-[N-methylsulfonyl-4-[4-(trifluoromethyl)phenoxy]anilino]propanamide
CFAMM00425598 CHEMBL252426 Bioactive (2S)-N-hydroxy-2-[methyl(propan-2-yl)amino]-3-[N-methylsulfonyl-4-[4-(trifluoromethyl)phenoxy]anilino]propanamide
CFAMM00425624 CHEMBL254509 Bioactive 1-[(2S)-1-(hydroxyamino)-3-[N-methylsulfonyl-4-[4-(trifluoromethyl)phenoxy]anilino]-1-oxopropan-2-yl]-N-methylpiperidine-4-carboxamide
CFAMM00425637 CHEMBL253892 Bioactive (2S)-N-hydroxy-3-[N-methylsulfonyl-4-[4-(trifluoromethyl)phenoxy]anilino]-2-piperidin-1-ylpropanamide
CFAMM00425617 CHEMBL398351 Bioactive (2S)-2-(cyclopentylamino)-N-hydroxy-3-[4-(4-methylphenoxy)-N-methylsulfonylanilino]propanamide
CFAMM00425630 CHEMBL401404 Bioactive (2S)-N-hydroxy-2-(3-methoxyanilino)-3-[4-(4-methylphenoxy)-N-methylsulfonylanilino]propanamide
CFAMM00425610 CHEMBL251831 Bioactive (2S)-2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-N-hydroxy-3-[4-(4-methylphenoxy)-N-methylsulfonylanilino]propanamide
CFAMM00425623 CHEMBL400193 Bioactive (2S)-2-(benzylamino)-N-hydroxy-3-[4-(4-methylphenoxy)-N-methylsulfonylanilino]propanamide
CFAMM00425616 CHEMBL430210 Bioactive (2S)-2-(4-acetylpiperazin-1-yl)-N-hydroxy-3-[N-methylsulfonyl-4-[4-(trifluoromethyl)phenoxy]anilino]propanamide
CFAMM00425629 CHEMBL399029 Bioactive (2S)-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-N-hydroxy-3-[N-methylsulfonyl-4-[4-(trifluoromethyl)phenoxy]anilino]propanamide
CFAMM00425609 CHEMBL400641 Bioactive (2S)-N-hydroxy-3-[N-methylsulfonyl-4-[4-(trifluoromethyl)phenoxy]anilino]-2-morpholin-4-ylpropanamide
CFAMM00425621 CHEMBL254506 Bioactive (2S)-2-(3-fluoroanilino)-N-hydroxy-3-[4-(4-methylphenoxy)-N-methylsulfonylanilino]propanamide
CFAMM00425634 CHEMBL398265 Bioactive (2S)-N-hydroxy-3-[4-(4-methylphenoxy)-N-methylsulfonylanilino]-2-morpholin-4-ylpropanamide
CFAMM00425607 CHEMBL252827 Bioactive (2S)-N-hydroxy-3-[N-methylsulfonyl-4-[4-(trifluoromethyl)phenoxy]anilino]-2-(propan-2-ylamino)propanamide
CFAMM00425620 CHEMBL254293 Bioactive (2S)-2-anilino-N-hydroxy-3-[4-(4-methylphenoxy)-N-methylsulfonylanilino]propanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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