CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14032
Family Name Somatostatin receptor type 1 and Somatostatin receptor type 2 ligand [(6aR,9R,10aR)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-yl]-[4-(3,4-difluorophenyl)piperazin-1-yl]methanone family
No. of Seeds 3 No. of Other Members 8
Family Centroid CFAMM00425797 Functional Category Bioactive with Natural Product
Superfamily Somatostatin receptor type 1 and Somatostatin receptor type 2 Binder Superfamily 4
Class Class 173

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Reverse transcriptase Inhibitor IDX899 Family 2 118
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Dihydroorotate dehydrogenase Inhibitor Nsc 665564 Family 2 83
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Calcitonin gene-related peptide type 1 receptor ligand CHEMBL1... 5 8
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cannabinoid receptor 1 ligand AGN-PC-04YSUM family 7 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Cathepsin K inhibitor (1R,2R)-2-(6-chloro-1,3,4,5-tetrahydropy... 2 0
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Prostaglandin D2 receptor 2 ligand 2-[(3R)-3-(3,3-diphenylprop... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5551829 f... 1 14
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Somatostatin receptor type 1 and 5-hydroxytryptamine receptor ... 2 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 18
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 5
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 4 11
5-hydroxytryptamine receptor 5A and 5-hydroxytryptamine recept... 2 0
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00425783 CHEMBL539415 Bioactive [(6aR,9R,10aR)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-yl]-[4-(4-chlorophenyl)piperazin-1-yl]methanone
CFAMM00425797 CHEMBL252618 Bioactive [(6aR,9R,10aR)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-yl]-[4-(3,4-difluorophenyl)piperazin-1-yl]methanone
CFAMM00425794 CHEMBL254287 Bioactive [(6aR,9R,10aR)-5-bromo-7-ethyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-yl]-[4-(3,4-difluorophenyl)piperazin-1-yl]methanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27619 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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