CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14039
Family Name C-X-C chemokine receptor type 3 ligand AGN-PC-07CQOB family
No. of Seeds 17 No. of Other Members 10
Family Centroid CFAMM00425833 Functional Category Bioactive
Superfamily C-X-C chemokine receptor type 3 Binder Superfamily 2
Class Class 4921

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Prothrombin Inhibitor Dabigatran Family 7 182
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[3-(4-cyanoph... 3 0
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-cyanoph... 1 0
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-cyanoph... 9 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00425821 CHEMBL252819 Bioactive N-[(1R)-1-[3-(4-cyanophenyl)-1,8-naphthyridin-2-yl]ethyl]-N-(2-ethylsulfonylethyl)-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamide
CFAMM00425834 CHEMBL570858 Bioactive N-[(1R)-1-[3-(4-cyanophenyl)-8-cyclopropylimidazo[1,2-a]pyrazin-2-yl]ethyl]-N-[(1,1-dioxothian-4-yl)methyl]-2-[4-(trifluoromethyl)phenyl]acetamide
CFAMM00425827 CHEMBL400736 Bioactive SureCN13150965
CFAMM00425840 CHEMBL570665 Bioactive N-[(1R)-1-[3-(4-cyanophenyl)-8-cyclopropylimidazo[1,2-a]pyrazin-2-yl]ethyl]-N-(2-ethylsulfonylethyl)-2-[3-fluoro-4-(trifluoromethyl)phenyl]acetamide
CFAMM00425833 CHEMBL570857 Bioactive AGN-PC-07CQOB
CFAMM00425826 CHEMBL578189 Bioactive N-[(1R)-1-[3-(4-cyanophenyl)-8-ethylimidazo[1,2-a]pyrazin-2-yl]ethyl]-N-(2-ethylsulfonylethyl)-2-[3-fluoro-4-(trifluoromethyl)phenyl]acetamide
CFAMM00425832 CHEMBL272720 Bioactive N-[(1R)-1-[1-(4-cyanophenyl)-4-pyridin-3-ylimidazol-2-yl]ethyl]-N-(2-ethylsulfonylethyl)-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamide
CFAMM00425825 CHEMBL578188 Bioactive N-[(1R)-1-[3-(4-cyanophenyl)-8-methylimidazo[1,2-a]pyrazin-2-yl]ethyl]-N-(2-ethylsulfonylethyl)-2-[3-fluoro-4-(trifluoromethyl)phenyl]acetamide
CFAMM00425844 CHEMBL577108 Bioactive N-[(1R)-1-[3-(4-cyanophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl]ethyl]-N-(2-ethylsulfonylethyl)-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamide
CFAMM00425824 CHEMBL578187 Bioactive N-[(1R)-1-[3-(4-cyanophenyl)-8-methoxyimidazo[1,2-a]pyrazin-2-yl]ethyl]-N-(2-ethylsulfonylethyl)-2-[3-fluoro-4-(trifluoromethyl)phenyl]acetamide
CFAMM00425830 CHEMBL270821 Bioactive N-[(1R)-1-[1-(4-cyanophenyl)-4-pyridin-2-ylimidazol-2-yl]ethyl]-N-(2-ethylsulfonylethyl)-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamide
CFAMM00425823 CHEMBL577973 Bioactive AGN-PC-07CQO6
CFAMM00425836 CHEMBL578192 Bioactive N-[(1R)-1-[3-(4-cyanophenyl)-8-cyclopropylimidazo[1,2-a]pyrazin-2-yl]ethyl]-N-[(1,1-dioxothian-4-yl)methyl]-2-[3-fluoro-4-(trifluoromethyl)phenyl]acetamide
CFAMM00425829 CHEMBL576098 Bioactive N-[(1R)-1-[3-(4-cyanophenyl)-8-cyclopropylimidazo[1,2-a]pyrazin-2-yl]ethyl]-N-[(1,1-dioxothian-4-yl)methyl]-2-[3-(trifluoromethyl)phenyl]acetamide
CFAMM00425842 CHEMBL398941 Bioactive SureCN3227242
CFAMM00425822 CHEMBL577972 Bioactive AGN-PC-07CQO5
CFAMM00425828 CHEMBL576097 Bioactive N-[(1R)-1-[3-(4-cyanophenyl)-8-cyclopropylimidazo[1,2-a]pyrazin-2-yl]ethyl]-N-[(1,1-dioxothian-4-yl)methyl]-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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