CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14044
Family Name RAC-alpha serine/threonine-protein kinase and RAC-beta serine/threonine-protein kinase inhibitor Pyridopyrimidine, 13f family
No. of Seeds 1 No. of Other Members 5
Family Centroid CFAMM00327347 Functional Category Bioactive
Superfamily Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-5-yl-urea Superfamily
Class Class 144

Cousin Family NamesSeedsMembers
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 15 457
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
GDC-0349 family 44 77
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Adenosine kinase inhibitor abt-702 family 14 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Integrin beta-3 and Integrin alpha-V inhibitor (3R)-3-quinolin... 6 8
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... 2 1
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Adenosine kinase inhibitor SureCN8248615 family 2 3
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Gonadotropin-releasing hormone receptor ligand AGN-PC-00AWCA f... 1 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
C-C chemokine receptor type 5 ligand AC1MHPAK family 5 1
Adenosine kinase inhibitor AGN-PC-074DKZ family 1 0
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27075 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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