CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14067
Family Name Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-methoxy-4,6-dimethylphenyl)-N,N-dipropylisoquinolin-4-amine family
No. of Seeds 5 No. of Other Members 15
Family Centroid CFAMM00426004 Functional Category Bioactive
Superfamily Tubulin beta-2B chain and Capsid scaffolding protein Binder Superfamily
Class Class 2031

Cousin Family NamesSeedsMembers
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Progesterone receptor and Glucocorticoid receptor ligand (5Z)-... 5 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YUW... 2 9
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YQD... 1 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Coagulation factor X and Prothrombin inhibitor AGN-PC-0759SH f... 5 4
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Corticotropin-releasing factor receptor 1 ligand 6-ethyl-3-met... 6 10
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[4... 7 4
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
Reverse transcriptase/RNaseH inhibitor AC1L9RKO family 2 17
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00426004 CHEMBL253913 Bioactive 3-ethyl-1-(2-methoxy-4,6-dimethylphenyl)-N,N-dipropylisoquinolin-4-amine
CFAMM00425997 CHEMBL404351 Bioactive N-(cyclopropylmethyl)-1-(2-methoxy-4,6-dimethylphenyl)-3-methyl-N-propylisoquinolin-4-amine
CFAMM00426001 CHEMBL438888 Bioactive 1-(2-methoxy-4,6-dimethylphenyl)-3-methyl-N,N-dipropylisoquinolin-4-amine
CFAMM00425999 CHEMBL253699 Bioactive 1-[2,4-bis(2,2-difluoroethyl)-6-methoxyphenyl]-3-methyl-N,N-dipropylisoquinolin-4-amine
CFAMM00426005 CHEMBL253914 Bioactive N,N-bis(cyclopropylmethyl)-1-(2-methoxy-4,6-dimethylphenyl)-3-methylisoquinolin-4-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27036 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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