CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1407
Family Name Bifunctional dihydrofolate reductase-thymidylate synthase and Dihydrofolate reductase inhibitor AGN-PC-07YQ41 family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00043204 Functional Category Bioactive
Superfamily Peptide deformylase, mitochondrial Inhibitor Trimetrexate Superfamily
Class Class 377

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Epidermal growth factor receptor and Receptor tyrosine-protein... 9 65
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
Receptor tyrosine-protein kinase erbB-2 Inhibitor ARRY-380 Family 2 2
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Survival motor neuron protein inhibitor CHEMBL1307497 family 1 2
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Dihydrofolate reductase inhibitor 7-(3,4-dimethoxyphenyl)-6-me... 1 3
Dihydrofolate reductase inhibitor 3-(2,4-diamino-6-methylquina... 2 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Receptor tyrosine-protein kinase erbB-2 and Tyrosine-protein k... 1 0
ALK tyrosine kinase receptor and Insulin-like growth factor 1 ... 1 4
Platelet-derived growth factor receptor beta and Mast/stem cel... 1 0
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Histone-lysine N-methyltransferase EHMT2 inhibitor N-(1-cyclop... 1 2
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 9 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 7
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
Dual specificity protein kinase CLK4 and Dual specificity tyro... 6 2
Vascular endothelial growth factor receptor 2 and Serine/threo... 4 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00323086 CHEMBL1165306 Bioactive AGN-PC-080QLN

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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