CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14089
Family Name Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[4-butoxy-3-(3-phenyl-3-bicyclo[2.2.1]heptanyl)phenoxy]methyl]quinoline family
No. of Seeds 7 No. of Other Members 4
Family Centroid CFAMM00426178 Functional Category Bioactive
Superfamily Squalene synthase Inhibitor ER-119884 Superfamily
Class Class 1076

Cousin Family NamesSeedsMembers
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Leukotriene B4 receptor 1 Ligand SB-209247 Family 7 24
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 18
Cysteinyl leukotriene receptor 1 ligand 4-[(2S)-2-[[7-(quinoli... 6 15
Cysteinyl leukotriene receptor 1 ligand SureCN9053715 family 2 11
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
Arachidonate 5-lipoxygenase inhibitor (2E)-2-[2-butyl-1-[4-(qu... 1 12
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 16 5
Coagulation factor X and Prothrombin inhibitor AGN-PC-0759SH f... 5 4
Cysteinyl leukotriene receptor 1 and Peripheral myelin protein... 1 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-met... 3 0
Arachidonate 5-lipoxygenase-activating protein inhibitor 5-[2-... 7 1
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... 2 4
Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... 5 15
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 3 5
Disintegrin and metalloproteinase domain-containing protein 17... 8 0
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
Cysteinyl leukotriene receptor 1 ligand 4-oxo-7-[[3-(quinolin-... 4 17
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Prothrombin and Trypsin-1 inhibitor AGN-PC-074I4I family 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Proteinase-activated receptor 1 ligand (3R,3aS,4S,4aR,8aS,9aR)... 1 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Thyroid hormone receptor beta and Cytochrome P450 2C19 ligand ... 1 0
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R,... 2 0
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
Proteinase-activated receptor 1 ligand 2-[2-[(E)-2-[(3R,3aS,4S... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00426180 CHEMBL403199 Bioactive ethyl 4-[2-(3-phenyl-3-bicyclo[2.2.1]heptanyl)-4-(quinolin-2-ylmethoxy)phenoxy]butanoate
CFAMM00426186 CHEMBL256976 Bioactive SureCN3578341
CFAMM00426179 CHEMBL430038 Bioactive 2-[[3-(3-phenyl-3-bicyclo[2.2.1]heptanyl)-4-phenylmethoxyphenoxy]methyl]quinoline
CFAMM00426185 CHEMBL256975 Bioactive 4-[2-(3-phenyl-3-bicyclo[2.2.1]heptanyl)-4-(quinolin-2-ylmethoxy)phenoxy]butanoic acid
CFAMM00426178 CHEMBL257621 Bioactive 2-[[4-butoxy-3-(3-phenyl-3-bicyclo[2.2.1]heptanyl)phenoxy]methyl]quinoline
CFAMM00426183 CHEMBL438166 Bioactive N,N-dimethyl-2-[2-(3-phenyl-3-bicyclo[2.2.1]heptanyl)-4-(quinolin-2-ylmethoxy)phenoxy]ethanamine
CFAMM00426182 CHEMBL254547 Bioactive 2-[[4-(2-methylsulfonylethoxy)-3-(3-phenyl-3-bicyclo[2.2.1]heptanyl)phenoxy]methyl]quinoline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26393 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543