CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14099
Family Name Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2-(1-phenylcyclopentyl)-4-(quinolin-2-ylmethoxy)phenoxy]methyl]quinoline family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00426211 Functional Category Bioactive
Superfamily Squalene synthase Inhibitor ER-119884 Superfamily
Class Class 1076

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
PF-02545920 family 16 140
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
Arachidonate 5-lipoxygenase-activating protein inhibitor 5-[2-... 7 1
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[4... 7 4
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 3 5
Renin inhibitor SureCN6043852 family 2 0
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Arachidonate 5-lipoxygenase-activating protein inhibitor SureC... 4 0
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00426211 CHEMBL404015 Bioactive 2-[[2-(1-phenylcyclopentyl)-4-(quinolin-2-ylmethoxy)phenoxy]methyl]quinoline
CFAMM00426217 CHEMBL255227 Bioactive 2-[[4-(1,2-dihydropyridin-5-ylmethoxy)-3-(1-phenylcyclopentyl)phenoxy]methyl]quinoline
CFAMM00426216 CHEMBL254747 Bioactive 2-[[3-(3-phenyl-3-bicyclo[2.2.1]heptanyl)-4-(pyridin-2-ylmethoxy)phenoxy]methyl]quinoline
CFAMM00426215 CHEMBL404276 Bioactive [2-(1-phenylcyclopentyl)-4-(quinolin-2-ylmethoxy)phenyl] N-pyridin-3-ylcarbamate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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