CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14100
Family Name Kappa-type opioid receptor and Mu-type opioid receptor ligand 2-[2-(dimethylsulfamoyl)-4,5-dimethoxyphenyl]-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide family
No. of Seeds 12 No. of Other Members 3
Family Centroid CFAMM00426224 Functional Category Bioactive
Superfamily Kappa-type opioid receptor and Niemann-Pick C1 protein Binder Superfamily
Class Class 3612

Cousin Family NamesSeedsMembers
Endothelin-1 receptor Ligand Atrasentan Family 127 336
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Intercellular adhesion molecule 1 Inhibitor Dehydropipernonali... 5 36
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-075O... 14 27
Matrix metalloproteinase-15 and Matrix metalloproteinase-16 in... 1 0
Bone morphogenetic protein 1 inhibitor benzyl N-[(4R)-4-[1,3-b... 6 25
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Calpain-1 catalytic subunit inhibitor 2-ethyl-1,1-dioxo-N-[(2S... 4 30
Bone morphogenetic protein 1 inhibitor (2R)-2-[1,3-benzodioxol... 2 1
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00426229 CHEMBL429677 Bioactive 2-(4,5-dimethoxy-2-morpholin-4-ylsulfonylphenyl)-N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methylacetamide
CFAMM00426222 CHEMBL401594 Bioactive 2-[2-[benzyl(methyl)sulfamoyl]-4,5-dimethoxyphenyl]-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide
CFAMM00426228 CHEMBL254960 Bioactive 2-[2-(dimethylsulfamoyl)-4,5-dimethoxyphenyl]-N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methylacetamide
CFAMM00426227 CHEMBL254754 Bioactive 2-[4,5-dimethoxy-2-(4-methylpiperazin-1-yl)sulfonylphenyl]-N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methylacetamide
CFAMM00426220 CHEMBL257355 Bioactive 2-(4,5-dimethoxy-2-pyrrolidin-1-ylsulfonylphenyl)-N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methylacetamide
CFAMM00426219 CHEMBL437784 Bioactive 2-[4,5-dimethoxy-2-(4-methylpiperazin-1-yl)sulfonylphenyl]-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide
CFAMM00426218 CHEMBL402820 Bioactive 2-(4,5-dimethoxy-2-pyrrolidin-1-ylsulfonylphenyl)-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide
CFAMM00426224 CHEMBL254959 Bioactive 2-[2-(dimethylsulfamoyl)-4,5-dimethoxyphenyl]-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide
CFAMM00426230 CHEMBL257139 Bioactive 2-[6-(dimethylsulfamoyl)-1,3-benzodioxol-5-yl]-N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methylacetamide
CFAMM00426223 CHEMBL257140 Bioactive 2-[6-[benzyl(methyl)sulfamoyl]-1,3-benzodioxol-5-yl]-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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