CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1411
Family Name Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(phenylmethyl)-1,4-butanediyl)bis(iminocarbonyl-2,1-phenylene))bis-, bis(2-pyridinylmethyl) ester, (1S-(1R*,2R*,4R*))- family
No. of Seeds 21 No. of Other Members 1
Family Centroid CFAMM00323116 Functional Category Bioactive
Superfamily Pol polyprotein Binder Superfamily 12
Class Class 137

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Indinavir Family 36 211
HIV protease Inhibitor Saquinavir Family 64 428
5-hydroxytryptamine receptor 3A Ligand Dolasetron Family 12 171
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
HIV-1 protease Inhibitor Atazanavir Family 16 58
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
Histone deacetylase 1 Inhibitor MS-275 Family 4 41
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Coagulation factor X Inhibitor Otamixaban Family 9 21
CP-18770 family 6 27
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Renin Inhibitor CP-305202 Family 9 30
Endothelin B receptor Ligand IRL-2500 Family 34 87
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-[3... 1 2
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0
Pol polyprotein inhibitor AC1LAD48 family 19 5
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Plasmepsin-1 and Plasmepsin-2 inhibitor Statine-like inhibitor... 13 5
Neutrophil elastase inhibitor SureCN7284457 family 4 6
Pol polyprotein inhibitor N-[3-[[(4R,5R,6R)-4-benzyl-5-hydroxy... 1 0
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... 7 9
Pol polyprotein inhibitor AC1LAMRC family 3 0
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 8 8
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Pol polyprotein inhibitor BEJ family 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... 3 1
Pol polyprotein and Protease inhibitor Palinavir family 1 0
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 4 53
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
C-C chemokine receptor type 1 ligand N-[(2S,3S,5R)-5-carbamoyl... 10 4
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 4
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 1 0
Pol polyprotein inhibitor AC1LAHQ9 family 8 15
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16b ... 2 0
Pol polyprotein inhibitor AC1LAHRX family 4 0
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3S)-1-cyclohexyl-3-h... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7013744... 2 3
Rho-associated protein kinase 2 inhibitor 2-hydroxyethyl 3-[2-... 2 0
Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0
Pol polyprotein inhibitor Palinavir deriv. 13 family 1 0
Neutrophil collagenase and Stromelysin-3 inhibitor [3-[[1-amin... 3 2
Pol polyprotein inhibitor 183854-15-1 family 3 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
Pol polyprotein inhibitor AC1LAMQU family 2 0
Pol polyprotein inhibitor (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3S)... 1 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 9 3
Beta-secretase 1 and Cathepsin B inhibitor SureCN14347784 family 4 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 4 0
Pol polyprotein inhibitor 173094-24-1 family 1 0
Pol polyprotein inhibitor AC1LA6OV family 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00323120 CHEMBL118362 Bioactive AC1LAMPO
CFAMM00323134 CHEMBL325499 Bioactive AC1LAMPF
CFAMM00323113 CHEMBL119898 Bioactive pyridin-2-ylmethyl N-[2-[[(2S,4S,5S)-5-[[(2S,3S)-2-(ethoxycarbonylamino)-3-methylpentanoyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]carbamoyl]phenyl]carbamate
CFAMM00323127 CHEMBL333290 Bioactive AC1LAMPU
CFAMM00323119 CHEMBL324157 Bioactive AC1LAMQI
CFAMM00323133 CHEMBL120141 Bioactive [(3R)-oxolan-3-yl] N-[(2S,3R,4S,5S)-3,4-dihydroxy-1,6-diphenyl-5-[[2-(pyridin-2-ylmethoxycarbonylamino)benzoyl]amino]hexan-2-yl]carbamate
CFAMM00323112 CHEMBL118531 Bioactive AC1LAMQR
CFAMM00323126 CHEMBL333392 Bioactive AC1LAMQC
CFAMM00323118 CHEMBL118221 Bioactive pyridin-2-ylmethyl N-[2-[[(2S,3R,4S,5S)-5-[(4-aminobenzoyl)amino]-3,4-dihydroxy-1,6-diphenylhexan-2-yl]carbamoyl]phenyl]carbamate
CFAMM00323132 CHEMBL408110 Bioactive 1,2,5,6-tetradeoxy-1,6-diphenyl-2,5-bis[(2-{[(pyridin-2-ylmethoxy)carbonyl]amino}benzoyl)amino]-l-altritol
CFAMM00323124 CHEMBL331199 Bioactive AC1LAMQO
CFAMM00323117 CHEMBL116482 Bioactive AC1LAMPX
CFAMM00323131 CHEMBL118513 Bioactive AC1LAMPR
CFAMM00323123 CHEMBL315742 Bioactive Carbamic acid, ((2-hydroxy-1,4-bis(phenylmethyl)-1,4-butanediyl)bis(iminocarbonyl-2,1-phenylene))bis-, bis(4-pyridinylmethyl) ester, (1S-(1R*,2R*,4R*))-
CFAMM00323116 CHEMBL313767 Bioactive Carbamic acid, ((2-hydroxy-1,4-bis(phenylmethyl)-1,4-butanediyl)bis(iminocarbonyl-2,1-phenylene))bis-, bis(2-pyridinylmethyl) ester, (1S-(1R*,2R*,4R*))-
CFAMM00323130 CHEMBL333420 Bioactive pyridin-2-ylmethyl N-[2-[[(2S,4S,5S)-5-[[(2R)-2-(ethoxycarbonylamino)-3-methylbutanoyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]carbamoyl]phenyl]carbamate
CFAMM00323122 CHEMBL331294 Bioactive AC1LAMQ0
CFAMM00323115 CHEMBL333781 Bioactive AC1LAMR3
CFAMM00323121 CHEMBL325527 Bioactive [(3R)-oxolan-3-yl] N-[(2S,3S,5S)-3-hydroxy-1,6-diphenyl-5-[[2-(pyridin-2-ylmethoxycarbonylamino)benzoyl]amino]hexan-2-yl]carbamate
CFAMM00323114 CHEMBL315500 Bioactive Carbamic acid, ((2-hydroxy-1,4-bis(phenylmethyl)-1,4-butanediyl)bis(iminocarbonyl-2,1-phenylene))bis-, bis(3-pyridinylmethyl) ester, (1S-(1R*,2R*,4R*))-
CFAMM00323128 CHEMBL333407 Bioactive AC1LAMPC

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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