CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14115
Family Name Histamine H3 receptor and Sodium-dependent serotonin transporter ligand 2-[4-(4-cyclopropyl-1,4-diazepane-1-carbonyl)-2-(methylaminomethyl)phenoxy]benzonitrile family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00275693 Functional Category Bioactive
Superfamily Peroxisome proliferator-activated receptor gamma and Peroxisome proliferator-activated receptor alpha Ligand KRP-297 Superfamily
Class Class 216

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Remoxipride Family 12 84
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Histamine H3 receptor Ligand A-317920 Family 9 240
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Mu-type opioid receptor ligand 3-[(3R,4R)-1-[(2,4-dimethoxyphe... 2 4
Histamine H3 receptor ligand 4-[[2-[2-[(2R)-2-methylpyrrolidin... 1 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 13 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 14 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 8 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00426292 CHEMBL257208 Bioactive 3-[4-(4-cyclopropyl-1,4-diazepane-1-carbonyl)-2-(methylaminomethyl)phenoxy]benzonitrile
CFAMM00426291 CHEMBL255127 Bioactive (4-cyclopropyl-1,4-diazepan-1-yl)-[3-(methylaminomethyl)-4-[2-(trifluoromethoxy)phenoxy]phenyl]methanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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