CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14116
Family Name Receptor tyrosine-protein kinase erbB-2 and Epidermal growth factor receptor ligand N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-3-(3-morpholin-4-ylpropoxy)-1H-pyrazolo[3,4-d]pyrimidin-4-amine family
No. of Seeds 14 No. of Other Members 3
Family Centroid CFAMM00393199 Functional Category Bioactive
Superfamily Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Superfamily
Class Class 1049

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Oxytocin receptor and Vasopressin V1a receptor Ligand PF-32741... 4 36
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YXQ ... 2 1
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Epidermal growth factor receptor and Tyrosine-protein kinase A... 4 3
Epidermal growth factor receptor and Cyclin-dependent kinase 1... 3 4
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 3 0
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro... 7 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 3
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
Receptor tyrosine-protein kinase erbB-2 ligand 2-[2-[4-[3-chlo... 4 5
Tyrosine-protein kinase JAK2 inhibitor N-[3-chloro-4-(4-methyl... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Acyl-CoA desaturase 1 inhibitor 3-[4-(2-chlorophenoxy)piperidi... 1 0
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 0
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
1-acyl-sn-glycerol-3-phosphate acyltransferase beta inhibitor ... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00426294 CHEMBL402553 Bioactive N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-3-(2-pyrrolidin-1-ylethoxy)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CFAMM00426300 CHEMBL271705 Bioactive N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-3-(2-morpholin-4-ylethoxy)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CFAMM00426299 CHEMBL257860 Bioactive 1-[3-[[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]oxy]propyl]piperidin-4-ol
CFAMM00426305 CHEMBL258282 Bioactive N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-3-[2-(4-methylpiperazin-1-yl)ethoxy]-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CFAMM00426298 CHEMBL257861 Bioactive 2-[[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]oxy]ethanol
CFAMM00426304 CHEMBL270448 Bioactive N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-3-[2-(oxazepan-2-yl)ethoxy]-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CFAMM00426303 CHEMBL258270 Bioactive 1-[4-[2-[[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]oxy]ethyl]piperazin-1-yl]ethanone
CFAMM00426296 CHEMBL257430 Bioactive N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-3-(2-piperazin-1-ylethoxy)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CFAMM00426309 CHEMBL255170 Bioactive 1-[2-[[4-[3-chloro-4-(6-methylpyridin-3-yl)oxyanilino]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]oxy]ethyl]piperidin-4-ol
CFAMM00426302 CHEMBL411897 Bioactive N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-3-[2-(4-methoxypiperidin-1-yl)ethoxy]-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CFAMM00426295 CHEMBL272935 Bioactive N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-3-[3-(4-methylpiperazin-1-yl)propoxy]-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CFAMM00426308 CHEMBL255135 Bioactive N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-3-[2-(methylamino)ethoxy]-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CFAMM00426301 CHEMBL404405 Bioactive 1-[2-[[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]oxy]ethyl]piperidin-4-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48694 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543