CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14132
Family Name Epidermal growth factor receptor and Receptor tyrosine-protein kinase erbB-2 ligand 1-[2-[[4-[4-[(3-fluorophenyl)methoxy]-3-methylanilino]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]oxy]ethyl]piperidin-4-ol family
No. of Seeds 5 No. of Other Members 0
Family Centroid CFAMM00426449 Functional Category Bioactive
Superfamily Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Superfamily
Class Class 851

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Mitogen-activated protein kinase 12 Inhibitor Birb 796 Family 20 43
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 37
Platelet-derived growth factor receptor beta and Ephrin type-B... 9 16
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YXQ ... 2 1
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 1 1
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 3 0
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 5
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Voltage-dependent calcium channel subunit alpha-2/delta-1 and ... 9 15
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro... 7 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 3
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 17
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 1
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
Aurora kinase A inhibitor SureCN4289024 family 1 0
Acyl-CoA desaturase 1 inhibitor 3-[4-(2-chlorophenoxy)piperidi... 1 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
Motilin receptor ligand SureCN2012437 family 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 12 2
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 9
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 14 3
Receptor tyrosine-protein kinase erbB-2 ligand SureCN3374869 f... 4 8
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 0
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor AGN-... 1 0
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN136... 1 0
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
Serine/threonine-protein kinase PLK1 inhibitor SureCN3992071 f... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00426450 CHEMBL255376 Bioactive 1-[2-[[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]oxy]ethyl]piperidin-4-ol
CFAMM00426449 CHEMBL438536 Bioactive 1-[2-[[4-[4-[(3-fluorophenyl)methoxy]-3-methylanilino]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]oxy]ethyl]piperidin-4-ol
CFAMM00426448 CHEMBL257873 Bioactive 1-[2-[[4-[3-fluoro-4-(6-methylpyridin-3-yl)oxyanilino]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]oxy]ethyl]piperidin-4-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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