CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14133
Family Name CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-fluorophenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]piperidin-1-yl]methyl]morpholine-4-carboxylate family
No. of Seeds 6 No. of Other Members 1
Family Centroid CFAMM00426455 Functional Category Bioactive
Superfamily Gp29 Inhibitor Tmpyp4 Superfamily
Class Class 1666

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Substance-P receptor Ligand GSK424887 Family 8 184
Glucagon receptor Ligand Dwlip-gcgrrx Family 5 26
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Histone deacetylase Inhibitor ST-5732 Family 8 6
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Protein kinase C theta type and Protein kinase C delta type in... 7 17
Protein kinase C theta type and Protein kinase C delta type in... 16 8
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 6
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 2
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Glucocorticoid receptor ligand SureCN5650626 family 17 25
Glucocorticoid receptor and Progesterone receptor ligand [(3R,... 6 2
Glucocorticoid receptor ligand SureCN4198717 family 5 0
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[2-(1H-ind... 1 0
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
CGMP-dependent protein kinase inhibitor AGN-PC-075XJ0 family 9 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Transporter and Sodium-dependent serotonin transporter inhibit... 2 1
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 4
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
C-C chemokine receptor type 2 ligand SureCN5946889 family 2 6
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Serine/threonine-protein kinase Chk1 inhibitor 5-[7-(2-morphol... 2 2
C-C chemokine receptor type 2 ligand SureCN5947024 family 11 0
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
CGMP-dependent protein kinase inhibitor AGN-PC-075INU family 1 1
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
CGMP-dependent protein kinase inhibitor 2-[[4-[5-(4-fluorophen... 1 0
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 1
2-carboxamide NP N-(2-(1h-indol-3-yl)ethyl)-5-methoxy-4-oxo-4h... 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00426454 CHEMBL404429 Bioactive methyl 2-[4-[5-(4-fluorophenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]piperidine-1-carbonyl]morpholine-4-carboxylate
CFAMM00426453 CHEMBL373046 Bioactive AGN-PC-075XI6
CFAMM00426452 CHEMBL255631 Bioactive 2-[[4-[5-(4-fluorophenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]piperidin-1-yl]methyl]-4-methylmorpholine
CFAMM00426458 CHEMBL255381 Bioactive [4-[5-(4-fluorophenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]piperidin-1-yl]-morpholin-2-ylmethanone
CFAMM00426457 CHEMBL272573 Bioactive 2-[[4-[5-(4-fluorophenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]piperidin-1-yl]methyl]morpholine
CFAMM00426455 CHEMBL256076 Bioactive methyl 2-[[4-[5-(4-fluorophenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]piperidin-1-yl]methyl]morpholine-4-carboxylate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

44518 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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