CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14143
Family Name C-C chemokine receptor type 2 and Potassium voltage-gated channel subfamily H member 2 ligand (1S,3R)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-propan-2-yl-3-(4-pyridin-3-ylpiperidin-1-yl)cyclopentane-1-carboxamide family
No. of Seeds 1 No. of Other Members 2
Family Centroid CFAMM00426520 Functional Category Bioactive
Superfamily C-C chemokine receptor type 2 and Potassium voltage-gated channel subfamily H member 2 Binder Superfamily 2
Class Class 1006

Cousin Family NamesSeedsMembers
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Histamine H1 receptor Ligand Triprolidine Family 19 316
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Coagulation factor X Inhibitor Otamixaban Family 9 21
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
ABC294640 family 5 75
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Aromatase Inhibitor Rogletimide Family 1 2
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
Platelet-activating factor receptor ligand YM-461 family 1 11
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 7 0
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
C-C chemokine receptor type 1 ligand [(1S)-3-[[(3S,4S)-3-metho... 1 15
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-(6-pyrrolid... 3 0
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 1
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Putative NP ZINC03999850 Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00426520 CHEMBL255513 Bioactive (1S,3R)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-propan-2-yl-3-(4-pyridin-3-ylpiperidin-1-yl)cyclopentane-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27397 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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