CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14144
Family Name Glucocorticoid receptor ligand 1-[(4aS)-6-(4-tert-butylphenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-N,N-dimethylmethanamine family
No. of Seeds 27 No. of Other Members 3
Family Centroid CFAMM00426550 Functional Category Bioactive
Superfamily Prostaglandin G/H synthase 2 Inhibitor Celecoxib Superfamily
Class Class 428

Cousin Family NamesSeedsMembers
Prostaglandin G/H synthase 2 Inhibitor Celecoxib Family 3 97
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
Metabotropic glutamate receptor 5 Ligand 3-(3-pyridin-2-yl-pyr... 4 24
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
5-hydroxytryptamine receptor 6 Ligand 4-(piperazin-1-yl)-3-tos... 18 75
Prostaglandin G/H synthase 2 Inhibitor SC-558 Family 1 2
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Glucocorticoid receptor ligand N-[(3S)-3-[1-(4-fluorophenyl)in... 11 24
Survival motor neuron protein and 15-hydroxyprostaglandin dehy... 1 35
5-hydroxytryptamine receptor 6 ligand AGN-PC-09QKIN family 2 9
Glucocorticoid receptor ligand 2,4,6-trimethyl-N-[(2S)-1-[[6-m... 16 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 13 1
5-hydroxytryptamine receptor 2A ligand SureCN5215979 family 2 10
Bifunctional epoxide hydrolase 2 and Prostaglandin G/H synthas... 7 20
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 10 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 1
Glucocorticoid receptor ligand (4aR)-1-(4-fluorophenyl)-4a-(me... 18 2
Glucocorticoid receptor ligand 4-[[(4aS)-6-(4-tert-butylphenyl... 4 0
Glucocorticoid receptor ligand 6-benzyl-1-(4-fluorophenyl)-4a-... 2 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 10
Progesterone receptor ligand AGN-PC-074LWG family 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 2 1
Prostaglandin D2 receptor 2 ligand SureCN2516080 family 1 0
Glucocorticoid receptor ligand N-ethyl-4-fluoro-N-[3,3,3-trifl... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Focal adhesion kinase 1 inhibitor 8-(4-ethylphenyl)-1,5-dimeth... 1 2
Dual specificity protein kinase TTK and Mitogen-activated prot... 1 2
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00426548 CHEMBL257079 Bioactive 6-(6-tert-butylpyridin-3-yl)sulfonyl-1-(4-fluorophenyl)-4a-[(4-fluorophenyl)methyl]-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
CFAMM00426528 CHEMBL270588 Bioactive 6-(4-tert-butylphenyl)sulfonyl-1-(4-fluorophenyl)-4a-[(4-fluorophenyl)methyl]-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
CFAMM00426541 CHEMBL403921 Bioactive 1-(4-fluorophenyl)-4a-[(4-fluorophenyl)methyl]-6-(4-methylphenyl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
CFAMM00426534 CHEMBL403179 Bioactive (4aS)-4a-(azetidin-1-ylmethyl)-6-(4-tert-butylphenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
CFAMM00426547 CHEMBL272923 Bioactive 2-[[(4aS)-6-(4-tert-butylphenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]methylamino]ethanol
CFAMM00426521 CHEMBL401864 Bioactive N-[[(4aS)-6-(4-tert-butylphenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]methyl]prop-2-en-1-amine
CFAMM00426527 CHEMBL411457 Bioactive (4aS)-1-(4-fluorophenyl)-4a-methyl-6-[4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
CFAMM00426540 CHEMBL403761 Bioactive N-[[(4aS)-6-(4-tert-butylphenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]methyl]-N-ethylethanamine
CFAMM00426533 CHEMBL257462 Bioactive (4aS)-6-(4-tert-butylphenyl)sulfonyl-1-(4-fluorophenyl)-4a-(piperidin-1-ylmethyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
CFAMM00426546 CHEMBL257204 Bioactive N-[[(4aS)-6-(4-tert-butylphenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]methyl]propan-2-amine
CFAMM00426526 CHEMBL270143 Bioactive N-[[(4aS)-6-(4-tert-butylphenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]methyl]-2-methoxyethanamine
CFAMM00426539 CHEMBL255521 Bioactive (4aS)-1-(4-fluorophenyl)-6-(4-fluorophenyl)sulfonyl-4a-methyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
CFAMM00426532 CHEMBL257203 Bioactive 1-[(4aS)-6-(benzenesulfonyl)-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-N,N-dimethylmethanamine
CFAMM00426545 CHEMBL409835 Bioactive (4aS)-6-(benzenesulfonyl)-1-(4-fluorophenyl)-4a-(piperidin-1-ylmethyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
CFAMM00426525 CHEMBL272788 Bioactive 1-(4-fluorophenyl)-4a-[(4-fluorophenyl)methyl]-6-(4-fluorophenyl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
CFAMM00426544 CHEMBL403334 Bioactive (4aS)-6-(4-tert-butylphenyl)sulfonyl-1-(4-fluorophenyl)-4a-[(4-methylpiperazin-1-yl)methyl]-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
CFAMM00426524 CHEMBL272789 Bioactive (4aS)-6-(4-tert-butylphenyl)sulfonyl-1-(4-fluorophenyl)-4a-methyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
CFAMM00426537 CHEMBL429913 Bioactive (4aS)-6-(4-tert-butylphenyl)sulfonyl-1-(4-fluorophenyl)-4a-(pyrrolidin-1-ylmethyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
CFAMM00426550 CHEMBL255950 Bioactive 1-[(4aS)-6-(4-tert-butylphenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-N,N-dimethylmethanamine
CFAMM00426543 CHEMBL256894 Bioactive (4aS)-6-(benzenesulfonyl)-1-(4-fluorophenyl)-4a-(pyrrolidin-1-ylmethyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
CFAMM00426523 CHEMBL256161 Bioactive (4aS)-4a-benzyl-6-(4-tert-butylphenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
CFAMM00426536 CHEMBL438386 Bioactive N-[[(4aS)-6-(4-tert-butylphenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]methyl]-N',N'-dimethylethane-1,2-diamine
CFAMM00426549 CHEMBL273141 Bioactive (4aS)-1-(4-fluorophenyl)-4a-methyl-6-(4-methylphenyl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
CFAMM00426529 CHEMBL255843 Bioactive 1-[(4aS)-1-(4-fluorophenyl)-6-(4-fluorophenyl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-N,N-dimethylmethanamine
CFAMM00426542 CHEMBL410037 Bioactive (4aS)-1-(4-fluorophenyl)-6-(4-fluorophenyl)sulfonyl-4a-(pyrrolidin-1-ylmethyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
CFAMM00426522 CHEMBL271019 Bioactive 6-(benzenesulfonyl)-1-(4-fluorophenyl)-4a-[(4-fluorophenyl)methyl]-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
CFAMM00426535 CHEMBL404160 Bioactive N-[[(4aS)-6-(4-tert-butylphenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]methyl]ethanamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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